Literature DB >> 21251911

Acidic extracellular pH induces p120-catenin-mediated disruption of adherens junctions via the Src kinase-PKCδ pathway.

Ying Chen1, Hsiu-Ni Kung, Chia-Hui Chen, Shih-Horng Huang, Kuo-Hsin Chen, Seu-Mei Wang.   

Abstract

An acidic microenvironment induces disruption of adherens junctions (AJs) of hepatoma cells. This study investigated the impact of an acidic extracellular pH (pHe) on p120-catenin (p120-ctn) serine phosphorylation. pH 6.6 treatment increased intracellular calcium levels, activated protein kinase C (PKC)α and PKCδ, and decreased serine phosphorylation of p120-ctn. Further knockdown of PKCα and δ by small interference RNA (siRNA) prevented the pH 6.6-induced downregulation of p120-ctn at AJ and the serine dephosphorylation of p120-ctn. Moreover, PP2 pretreatment and siRNA of c-Src abrogated the pH 6.6-induced PKCδ activation. Together, the c-Src-PKCδ cascade and PKCα regulate the acidic pHe-induced AJ disruption.
Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 21251911     DOI： 10.1016/j.febslet.2011.01.022

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

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Journal:  PLoS Pathog       Date:  2013-07-18       Impact factor: 6.823

8.  DIPA-family coiled-coils bind conserved isoform-specific head domain of p120-catenin family: potential roles in hydrocephalus and heterotopia.

Authors:  Nicholas O Markham; Caleb A Doll; Michael R Dohn; Rachel K Miller; Huapeng Yu; Robert J Coffey; Pierre D McCrea; Joshua T Gamse; Albert B Reynolds
Journal:  Mol Biol Cell       Date:  2014-07-09       Impact factor: 4.138
  8 in total

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