| Literature DB >> 21247804 |
Nicholas Chim1, Jeff E Habel, Jodie M Johnston, Inna Krieger, Linda Miallau, Ramasamy Sankaranarayanan, Robert P Morse, John Bruning, Stephanie Swanson, Haelee Kim, Chang-Yub Kim, Hongye Li, Esther M Bulloch, Richard J Payne, Alexandra Manos-Turvey, Li-Wei Hung, Edward N Baker, J Shaun Lott, Michael N G James, Thomas C Terwilliger, David S Eisenberg, James C Sacchettini, Celia W Goulding.
Abstract
The TB Structural Genomics Consortium is a worldwide organization of collaborators whose mission is the comprehensive structural determination and analyses of Mycobacterium tuberculosis proteins to ultimately aid in tuberculosis diagnosis and treatment. Congruent to the overall vision, Consortium members have additionally established an integrated facilities core to streamline M. tuberculosis structural biology and developed bioinformatics resources for data mining. This review aims to share the latest Consortium developments with the TB community, including recent structures of proteins that play significant roles within M. tuberculosis. Atomic resolution details may unravel mechanistic insights and reveal unique and novel protein features, as well as important protein-protein and protein-ligand interactions, which ultimately lead to a better understanding of M. tuberculosis biology and may be exploited for rational, structure-based therapeutics design.Entities:
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Year: 2011 PMID： 21247804 PMCID： PMC3310434 DOI： 10.1016/j.tube.2010.11.009
Source DB: PubMed Journal: Tuberculosis (Edinb) ISSN： 1472-9792 Impact factor: 3.131