Literature DB >> 23261593

A new drug for an old bug.

Peter J Myler, Robin Stacy.   

Abstract

There is an urgent need to develop new drugs for the treatment of tuberculosis, particularly against latent/persistent forms of the causative agent, Mycobacterium tuberculosis. In this issue of Chemistry & Biology, Krieger and colleagues use a structure-guided approach to develop novel inhibitors of malate synthase, a target in the glyoxylate shunt that is critical for pathogen survival in chronic infection.
Copyright © 2012 Elsevier Ltd. All rights reserved.

Entities:  

Year:  2012        PMID： 23261593      PMCID： PMC3536450          DOI： 10.1016/j.chembiol.2012.12.003

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  7 in total

1.  Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis.

Authors:  V Sharma; S Sharma; K Hoener zu Bentrup; J D McKinney; D G Russell; W R Jacobs; J C Sacchettini
Journal:  Nat Struct Biol       Date:  2000-08

2.  Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection.

Authors:  Joeli Marrero; Kyu Y Rhee; Dirk Schnappinger; Kevin Pethe; Sabine Ehrt
Journal:  Proc Natl Acad Sci U S A       Date:  2010-05-03       Impact factor: 11.205

3.  Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase.

Authors:  J D McKinney; K Höner zu Bentrup; E J Muñoz-Elías; A Miczak; B Chen; W T Chan; D Swenson; J C Sacchettini; W R Jacobs; D G Russell
Journal:  Nature       Date:  2000-08-17       Impact factor: 49.962

Review 4.  The TB Structural Genomics Consortium: a decade of progress.

Authors:  Nicholas Chim; Jeff E Habel; Jodie M Johnston; Inna Krieger; Linda Miallau; Ramasamy Sankaranarayanan; Robert P Morse; John Bruning; Stephanie Swanson; Haelee Kim; Chang-Yub Kim; Hongye Li; Esther M Bulloch; Richard J Payne; Alexandra Manos-Turvey; Li-Wei Hung; Edward N Baker; J Shaun Lott; Michael N G James; Thomas C Terwilliger; David S Eisenberg; James C Sacchettini; Celia W Goulding
Journal:  Tuberculosis (Edinb)       Date:  2011-01-17       Impact factor: 3.131

5.  Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase.

Authors:  Inna V Krieger; Joel S Freundlich; Vijay B Gawandi; Justin P Roberts; Vidyadhar B Gawandi; Qingan Sun; Joshua L Owen; Maria T Fraile; Sofia I Huss; Jose-Luis Lavandera; Thomas R Ioerger; James C Sacchettini
Journal:  Chem Biol       Date:  2012-12-21

6.  Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis.

Authors:  Clare V Smith; Chih-chin Huang; Andras Miczak; David G Russell; James C Sacchettini; Kerstin Höner zu Bentrup
Journal:  J Biol Chem       Date:  2002-10-21       Impact factor: 5.157

7.  Evolution of glyoxylate cycle enzymes in Metazoa: evidence of multiple horizontal transfer events and pseudogene formation.

Authors:  Fyodor A Kondrashov; Eugene V Koonin; Igor G Morgunov; Tatiana V Finogenova; Marie N Kondrashova
Journal:  Biol Direct       Date:  2006-10-23       Impact factor: 4.540
  7 in total
  2 in total

Review 1.  Tuberculosis drug discovery in the post-post-genomic era.

Authors:  Benoit Lechartier; Jan Rybniker; Alimuddin Zumla; Stewart T Cole
Journal:  EMBO Mol Med       Date:  2014-01-08       Impact factor: 12.137

2.  Theranostic Application of a Novel G-Quadruplex-Forming DNA Aptamer Targeting Malate Synthase of Mycobacterium tuberculosis.

Authors:  Abhijeet Dhiman; Chanchal Kumar; Subodh Kumar Mishra; Kriti Sikri; Ishara Datta; Pradeep Sharma; Tej P Singh; Sagarika Haldar; Neera Sharma; Anjali Bansal; Yusra Ahmad; Amit Kumar; Tarun Kumar Sharma; Jaya Sivaswami Tyagi
Journal:  Mol Ther Nucleic Acids       Date:  2019-10-04       Impact factor: 8.886
  2 in total

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