OBJECTIVE: To examine the causal contribution of conization to premature delivery. METHODS: This was a retrospective, case-control, multicenter study of women who underwent conization in 5 hospitals in the Basque Country (Spain) from 1998 to 2007. Three study groups were established: group A, post-conization infant deliveries; control group B, pre-conization infant deliveries; and control group C, infant deliveries without conization. RESULTS: Comparing group A with group C, there was a higher rate of preterm delivery before 35 weeks (5.3% versus 1.6%), a lower mean birth weight (3156.2g versus 3328.5 g), and a greater prevalence of infants under 2500 g (10.6% versus 3.7%). There were no significant differences between group A and group B: preterm delivery before 35 weeks (5.3% versus 4.8%), mean birth weight (3156.2g versus 3119.4 g), and prevalence of infants under 2500 g (10.6% versus 10.6%). CONCLUSION: Pregnancy in women post-conization was associated with a risk of preterm delivery. However, there were no significant differences between women who underwent conization before and those who underwent conization after delivery. Cervical conization does not necessarily increase the risk of preterm delivery in subsequent pregnancy. Conization should be considered an indicator of such risk because it is associated with pregnancy complications arising from socio-epidemiologic factors present in women requiring conization that are also present in women who have premature delivery.
OBJECTIVE: To examine the causal contribution of conization to premature delivery. METHODS: This was a retrospective, case-control, multicenter study of women who underwent conization in 5 hospitals in the Basque Country (Spain) from 1998 to 2007. Three study groups were established: group A, post-conization infant deliveries; control group B, pre-conization infant deliveries; and control group C, infant deliveries without conization. RESULTS: Comparing group A with group C, there was a higher rate of preterm delivery before 35 weeks (5.3% versus 1.6%), a lower mean birth weight (3156.2g versus 3328.5 g), and a greater prevalence of infants under 2500 g (10.6% versus 3.7%). There were no significant differences between group A and group B: preterm delivery before 35 weeks (5.3% versus 4.8%), mean birth weight (3156.2g versus 3119.4 g), and prevalence of infants under 2500 g (10.6% versus 10.6%). CONCLUSION: Pregnancy in women post-conization was associated with a risk of preterm delivery. However, there were no significant differences between women who underwent conization before and those who underwent conization after delivery. Cervical conization does not necessarily increase the risk of preterm delivery in subsequent pregnancy. Conization should be considered an indicator of such risk because it is associated with pregnancy complications arising from socio-epidemiologic factors present in women requiring conization that are also present in women who have premature delivery.
Authors: Shayna N Conner; Alison G Cahill; Methodius G Tuuli; David M Stamilio; Anthony O Odibo; Kimberly A Roehl; George A Macones Journal: Obstet Gynecol Date: 2013-12 Impact factor: 7.661
Authors: Shayna N Conner; Heather A Frey; Alison G Cahill; George A Macones; Graham A Colditz; Methodius G Tuuli Journal: Obstet Gynecol Date: 2014-04 Impact factor: 7.661
Authors: Murat Öz; Nilüfer Çetinkaya; Elmas Korkmaz; Kerem Doğa Seçkin; Mehmet Mutlu Meydanlı; Tayfun Güngör Journal: J Turk Ger Gynecol Assoc Date: 2016-09-01
Authors: Soo Hyun Cho; Kyo Hoon Park; Eun Young Jung; Jung Kyung Joo; Ji Ae Jang; Ha Na Yoo Journal: J Korean Med Sci Date: 2017-03 Impact factor: 2.153
Authors: Maria Kyrgiou; Antonios Athanasiou; Maria Paraskevaidi; Anita Mitra; Ilkka Kalliala; Pierre Martin-Hirsch; Marc Arbyn; Phillip Bennett; Evangelos Paraskevaidis Journal: BMJ Date: 2016-07-28