Literature DB >> 21244047

Access to functionalized steroid side chains via modified Julia olefination.

Enver Cagri Izgu1, Aaron C Burns, Thomas R Hoye.   

Abstract

Various functionalized steroidal side chains were conveniently accessed by a modified Julia olefination strategy using a common sulfone donor and an appropriate α-branched aldehyde acceptor. For the coupling of these hindered classes of reaction partners (and in contrast to typically observed trends), the benzothiazolyl(BT)-sulfone anion gave superior outcomes compared to the phenyltetrazolyl(PT)-sulfone anion.

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Year:  2011        PMID： 21244047      PMCID： PMC3045753          DOI： 10.1021/ol102936z

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


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