| Literature DB >> 10986072 |
W A Kinney1, X Zhang, J I Williams, S Johnston, R S Michalak, M Deshpande, L Dostal, J P Rosazza.
Abstract
A short formal synthesis of squalamine is described, utilizing the biotransformation product 2, which is available in one step from commercially available 3-keto-23,24-bisnorchol-4-en-22-ol (1). Regioselective C-22 oxidation and C-24 sulfation of the corresponding alcohols in the presence of a free C-7 alcohol make for an efficient preparation of squalamine intermediate 11.Entities:
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Year: 2000 PMID： 10986072 DOI： 10.1021/ol0059495
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005