OBJECTIVE: Magnetic resonance imaging (MRI) studies report hippocampal (HC) volume reductions in depression. Despite observations of functional heterogeneity and ovarian steroid influence in the hippocampus, few studies report regional volume alterations or control for menstrual cycle phase. Using in vitro methods, we recently observed reduced anterior HC volume in antidepressant-naive, ovarian-intact, behaviorally depressed adult female monkeys. The purpose of this study was to confirm these findings in vivo and examine whether lack of ovarian steroids affects the relationship between depression and HC volume. METHODS: MRI was used to measure whole, anterior, and posterior HC volumes in a matched sample of antidepressant-naive, surgically postmenopausal adult female cynomolgus macaques characterized for behavioral depression (six depressed, six nondepressed). High-resolution structural MRIs were acquired, and HC regions of interest were manually segmented. HC volumes were normalized to whole brain volumes before analysis. RESULTS: Similar to the previous in vitro study, HC volume measured in vivo was associated with depression. In contrast to the previous study of ovarian-intact female monkeys, whole, anterior, and posterior volumes of both the left and right hippocampi were significantly smaller in depressed compared with nondepressed surgically postmenopausal female monkeys. CONCLUSIONS: These findings confirm and extend previous observations of smaller HC volumes in behaviorally depressed female monkeys and suggest a possible role for ovarian steroids in HC protection in depression. Further studies of the potential modulating effects of ovarian function on the relationship between depression and HC volume are warranted.
OBJECTIVE: Magnetic resonance imaging (MRI) studies report hippocampal (HC) volume reductions in depression. Despite observations of functional heterogeneity and ovarian steroid influence in the hippocampus, few studies report regional volume alterations or control for menstrual cycle phase. Using in vitro methods, we recently observed reduced anterior HC volume in antidepressant-naive, ovarian-intact, behaviorally depressed adult female monkeys. The purpose of this study was to confirm these findings in vivo and examine whether lack of ovarian steroids affects the relationship between depression and HC volume. METHODS: MRI was used to measure whole, anterior, and posterior HC volumes in a matched sample of antidepressant-naive, surgically postmenopausal adult female cynomolgus macaques characterized for behavioral depression (six depressed, six nondepressed). High-resolution structural MRIs were acquired, and HC regions of interest were manually segmented. HC volumes were normalized to whole brain volumes before analysis. RESULTS: Similar to the previous in vitro study, HC volume measured in vivo was associated with depression. In contrast to the previous study of ovarian-intact female monkeys, whole, anterior, and posterior volumes of both the left and right hippocampi were significantly smaller in depressed compared with nondepressed surgically postmenopausal female monkeys. CONCLUSIONS: These findings confirm and extend previous observations of smaller HC volumes in behaviorally depressed female monkeys and suggest a possible role for ovarian steroids in HC protection in depression. Further studies of the potential modulating effects of ovarian function on the relationship between depression and HC volume are warranted.
Authors: D M Bannerman; J N P Rawlins; S B McHugh; R M J Deacon; B K Yee; T Bast; W-N Zhang; H H J Pothuizen; J Feldon Journal: Neurosci Biobehav Rev Date: 2004-05 Impact factor: 8.989
Authors: Alexander Neumeister; Suzanne Wood; Omer Bonne; Allison C Nugent; David A Luckenbaugh; Theresa Young; Earle E Bain; Dennis S Charney; Wayne C Drevets Journal: Biol Psychiatry Date: 2005-04-15 Impact factor: 13.382
Authors: K Takuma; A Matsuo; Y Himeno; Y Hoshina; Y Ohno; Y Funatsu; S Arai; H Kamei; H Mizoguchi; T Nagai; K Koike; M Inoue; K Yamada Journal: Neuroscience Date: 2007-02-22 Impact factor: 3.590
Authors: Carol A Shively; Charles E Wood; Thomas C Register; Stephanie L Willard; Cynthia J Lees; Haiying Chen; Regine L Sitruk-Ware; Yun-Yen Tsong; J Mark Cline Journal: Psychoneuroendocrinology Date: 2007-09-04 Impact factor: 4.905
Authors: Carol A Shively; Thomas C Register; David P Friedman; Timothy M Morgan; Jalonda Thompson; Tasha Lanier Journal: Biol Psychol Date: 2005-01-07 Impact factor: 3.251
Authors: Christopher J Machado; Abraham Z Snyder; Simon R Cherry; Pierre Lavenex; David G Amaral Journal: Neuroimage Date: 2007-09-26 Impact factor: 6.556
Authors: Katherine M Reding; Martin M Styner; Mark E Wilson; Donna Toufexis; Mar M Sanchez Journal: Psychoneuroendocrinology Date: 2020-01-25 Impact factor: 4.905
Authors: Stephanie L Willard; Beth Uberseder; Ashlee Clark; James B Daunais; Warwick D Johnston; David Neely; Adreanna Massey; Jeff D Williamson; Robert A Kraft; J Daniel Bourland; Sara R Jones; Carol A Shively Journal: Neuropharmacology Date: 2015-06-24 Impact factor: 5.250
Authors: Melody V Wu; Jul Lea Shamy; Gillinder Bedi; Chien-Wen J Choi; Melanie M Wall; Victoria Arango; Maura Boldrini; Richard W Foltin; René Hen Journal: Neuropsychopharmacology Date: 2014-02-12 Impact factor: 7.853
Authors: Anisha Kalidindi; Sean D Kelly; Kaela S Singleton; Dora Guzman; Liana Merrill; Stephanie L Willard; Carol A Shively; Gretchen N Neigh Journal: Physiol Behav Date: 2016-07-14