BACKGROUND: Hippocampal volumes obtained from a group of medication-free, remitted subjects with recurrent major depressive disorder (MDD) were compared against corresponding measures from healthy controls. METHODS: Thirty-one subjects with recurrent MDD in full remission, and 57 healthy controls underwent high resolution magnetic resonance imaging (MRI) on a GE 3T scanner. Eight patients with MDD were medication-naive, and twenty-three MDD patients were off antidepressant medications for a mean of 30 months at the time of the MRI study. RESULTS: Patients showed smaller total and posterior hippocampal volume relative to controls. Anterior hippocampal volume did not differ between patients and controls. CONCLUSIONS: Recurrent depression is associated with smaller hippocampal volume which is most prominent in the posterior hippocampus. Smaller hippocampal volume appears to be a trait characteristic for MDD.
BACKGROUND: Hippocampal volumes obtained from a group of medication-free, remitted subjects with recurrent major depressive disorder (MDD) were compared against corresponding measures from healthy controls. METHODS: Thirty-one subjects with recurrent MDD in full remission, and 57 healthy controls underwent high resolution magnetic resonance imaging (MRI) on a GE 3T scanner. Eight patients with MDD were medication-naive, and twenty-three MDDpatients were off antidepressant medications for a mean of 30 months at the time of the MRI study. RESULTS:Patients showed smaller total and posterior hippocampal volume relative to controls. Anterior hippocampal volume did not differ between patients and controls. CONCLUSIONS: Recurrent depression is associated with smaller hippocampal volume which is most prominent in the posterior hippocampus. Smaller hippocampal volume appears to be a trait characteristic for MDD.
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Authors: M I Geerlings; S Sigurdsson; G Eiriksdottir; M E Garcia; T B Harris; T Sigurdsson; V Gudnason; L J Launer Journal: Psychol Med Date: 2012-05-30 Impact factor: 7.723
Authors: Giacomo Salvadore; Allison C Nugent; Herve Lemaitre; David A Luckenbaugh; Ruth Tinsley; Dara M Cannon; Alexander Neumeister; Carlos A Zarate; Wayne C Drevets Journal: Neuroimage Date: 2010-11-10 Impact factor: 6.556
Authors: Smita Thakker-Varia; Jennifer Jernstedt Krol; Jacob Nettleton; Parizad M Bilimoria; Debra A Bangasser; Tracey J Shors; Ira B Black; Janet Alder Journal: J Neurosci Date: 2007-11-07 Impact factor: 6.167