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Literature DB >> 21241891

Global regulation of H2A.Z localization by the INO80 chromatin-remodeling enzyme is essential for genome integrity.

Manolis Papamichos-Chronakis¹, Shinya Watanabe, Oliver J Rando, Craig L Peterson.

Abstract

INO80 is an evolutionarily conserved, ATP-dependent chromatin-remodeling enzyme that plays roles in transcription, DNA repair, and replication. Here, we show that yeast INO80 facilitates these diverse processes at least in part by controlling genome-wide distribution of the histone variant H2A.Z. In the absence of INO80, H2A.Z nucleosomes are mislocalized, and H2A.Z levels at promoters show reduced responsiveness to transcriptional changes, suggesting that INO80 controls H2A.Z dynamics. Additionally, we demonstrate that INO80 has a histone-exchange activity in which the enzyme can replace nucleosomal H2A.Z/H2B with free H2A/H2B dimers. Genetic interactions between ino80 and htz1 support a model in which INO80 catalyzes the removal of unacetylated H2A.Z from chromatin as a mechanism to promote genome stability.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 2011 PMID： 21241891 PMCID： PMC3035940 DOI： 10.1016/j.cell.2010.12.021

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

51 in total

1. Purification and biochemical properties of yeast SWI/SNF complex.

Authors: C Logie; C L Peterson
Journal: Methods Enzymol Date: 1999 Impact factor: 1.600

2. H2A.Z alters the nucleosome surface to promote HP1alpha-mediated chromatin fiber folding.

Authors: Jun Y Fan; Danny Rangasamy; Karolin Luger; David J Tremethick
Journal: Mol Cell Date: 2004-11-19 Impact factor: 17.970

3. Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin.

Authors: Ryan M Raisner; Paul D Hartley; Marc D Meneghini; Marie Z Bao; Chih Long Liu; Stuart L Schreiber; Oliver J Rando; Hiten D Madhani
Journal: Cell Date: 2005-10-21 Impact factor: 41.582

4. Genome-scale identification of nucleosome positions in S. cerevisiae.

Authors: Guo-Cheng Yuan; Yuen-Jong Liu; Michael F Dion; Michael D Slack; Lani F Wu; Steven J Altschuler; Oliver J Rando
Journal: Science Date: 2005-06-16 Impact factor: 47.728

5. Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange.

Authors: Wei-Hua Wu; Samar Alami; Edward Luk; Chwen-Huey Wu; Subhojit Sen; Gaku Mizuguchi; Debbie Wei; Carl Wu
Journal: Nat Struct Mol Biol Date: 2005-11-20 Impact factor: 15.369

6. Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants.

Authors: C Liang; B Stillman
Journal: Genes Dev Date: 1997-12-15 Impact factor: 11.361

7. Kar4p, a karyogamy-specific component of the yeast pheromone response pathway.

Authors: L J Kurihara; B G Stewart; A E Gammie; M D Rose
Journal: Mol Cell Biol Date: 1996-08 Impact factor: 4.272

8. Gene expression profiles of epithelial cells microscopically isolated from a breast-invasive ductal carcinoma and a nodal metastasis.

Authors: I Zucchi; E Mento; V A Kuznetsov; M Scotti; V Valsecchi; B Simionati; E Vicinanza; G Valle; S Pilotti; R Reinbold; P Vezzoni; A Albertini; R Dulbecco
Journal: Proc Natl Acad Sci U S A Date: 2004-12-17 Impact factor: 11.205

9. Genome-wide dynamics of Htz1, a histone H2A variant that poises repressed/basal promoters for activation through histone loss.

Authors: Haiying Zhang; Douglas N Roberts; Bradley R Cairns
Journal: Cell Date: 2005-10-21 Impact factor: 41.582

10. Single-nucleosome mapping of histone modifications in S. cerevisiae.

Authors: Chih Long Liu; Tommy Kaplan; Minkyu Kim; Stephen Buratowski; Stuart L Schreiber; Nir Friedman; Oliver J Rando
Journal: PLoS Biol Date: 2005-08-30 Impact factor: 8.029

197 in total

1. ATP-dependent chromatin remodeling factors tune S phase checkpoint activity.

Authors: Tracey J Au; Jairo Rodriguez; Jack A Vincent; Toshio Tsukiyama
Journal: Mol Cell Biol Date: 2011-09-19 Impact factor: 4.272

2. ATRX-mediated chromatin association of histone variant macroH2A1 regulates α-globin expression.

Authors: Kajan Ratnakumar; Luis F Duarte; Gary LeRoy; Dan Hasson; Daniel Smeets; Chiara Vardabasso; Clemens Bönisch; Tianying Zeng; Bin Xiang; David Y Zhang; Haitao Li; Xiaowo Wang; Sandra B Hake; Lothar Schermelleh; Benjamin A Garcia; Emily Bernstein
Journal: Genes Dev Date: 2012-03-01 Impact factor: 11.361

Global regulation of H2A.Z localization by the INO80 chromatin-remodeling enzyme is essential for genome integrity.

1. Purification and biochemical properties of yeast SWI/SNF complex.

2. H2A.Z alters the nucleosome surface to promote HP1alpha-mediated chromatin fiber folding.

3. Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin.

4. Genome-scale identification of nucleosome positions in S. cerevisiae.

5. Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange.

6. Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants.

7. Kar4p, a karyogamy-specific component of the yeast pheromone response pathway.

8. Gene expression profiles of epithelial cells microscopically isolated from a breast-invasive ductal carcinoma and a nodal metastasis.

9. Genome-wide dynamics of Htz1, a histone H2A variant that poises repressed/basal promoters for activation through histone loss.

10. Single-nucleosome mapping of histone modifications in S. cerevisiae.

1. ATP-dependent chromatin remodeling factors tune S phase checkpoint activity.

2. ATRX-mediated chromatin association of histone variant macroH2A1 regulates α-globin expression.

Review 3. New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?

Review 4. Patching Broken DNA: Nucleosome Dynamics and the Repair of DNA Breaks.

5. The MORC family: new epigenetic regulators of transcription and DNA damage response.

6. Constitutive turnover of histone H2A.Z at yeast promoters requires the preinitiation complex.

7. H2A.Z-dependent regulation of cohesin dynamics on chromosome arms.

Review 8. Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes.

Review 9. Chromatin remodeling at DNA double-strand breaks.

10. A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme.