Literature DB >> 21234492

The de novo engineering of pyrrolysyl-tRNA synthetase for genetic incorporation of L-phenylalanine and its derivatives.

Yane-Shih Wang1, William K Russell, Zhiyong Wang, Wei Wan, Lindsey E Dodd, Pei-Jing Pai, David H Russell, Wenshe R Liu.   

Abstract

Using evolved pyrrolysyl-tRNA synthetase-tRNA(CUA)(Pyl) pairs, L-phenylalanine, p-iodo-L-phenylalanine and p-bromo-L-phenylalanine have been genetically incorporated into proteins at amber mutation sites in E. coli.

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Year:  2011        PMID： 21234492     DOI： 10.1039/c0mb00217h

Source DB:  PubMed          Journal:  Mol Biosyst        ISSN： 1742-2051


  33 in total

1.  Pyrrolysyl-tRNA synthetase variants reveal ancestral aminoacylation function.

Authors:  Jae-hyeong Ko; Yane-Shih Wang; Akiyoshi Nakamura; Li-Tao Guo; Dieter Söll; Takuya Umehara
Journal:  FEBS Lett       Date:  2013-08-28       Impact factor: 4.124

2.  A rationally designed pyrrolysyl-tRNA synthetase mutant with a broad substrate spectrum.

Authors:  Yane-Shih Wang; Xinqiang Fang; Ashley L Wallace; Bo Wu; Wenshe R Liu
Journal:  J Am Chem Soc       Date:  2012-02-06       Impact factor: 15.419

Review 3.  Arylation Chemistry for Bioconjugation.

Authors:  Chi Zhang; Ekaterina V Vinogradova; Alexander M Spokoyny; Stephen L Buchwald; Bradley L Pentelute
Journal:  Angew Chem Int Ed Engl       Date:  2019-02-15       Impact factor: 15.336

4.  A genetically encoded aldehyde for rapid protein labelling.

Authors:  Alfred Tuley; Yan-Jiun Lee; Bo Wu; Zhiyong U Wang; Wenshe R Liu
Journal:  Chem Commun (Camb)       Date:  2014-07-18       Impact factor: 6.222

Review 5.  Pyrrolysyl-tRNA synthetase: an ordinary enzyme but an outstanding genetic code expansion tool.

Authors:  Wei Wan; Jeffery M Tharp; Wenshe R Liu
Journal:  Biochim Biophys Acta       Date:  2014-03-12

6.  Catalyst-free and site-specific one-pot dual-labeling of a protein directed by two genetically incorporated noncanonical amino acids.

Authors:  Bo Wu; Zhiyong Wang; Ying Huang; Wenshe R Liu
Journal:  Chembiochem       Date:  2012-05-24       Impact factor: 3.164

7.  Synthesis and Explosion Hazards of 4-Azido-l-phenylalanine.

Authors:  Mark B Richardson; Derek B Brown; Carlos A Vasquez; Joseph W Ziller; Kevin M Johnston; Gregory A Weiss
Journal:  J Org Chem       Date:  2018-04-02       Impact factor: 4.354

8.  Multiple site-selective insertions of noncanonical amino acids into sequence-repetitive polypeptides.

Authors:  I-Lin Wu; Melissa A Patterson; Holly E Carpenter Desai; Ryan A Mehl; Gianluca Giorgi; Vincent P Conticello
Journal:  Chembiochem       Date:  2013-04-26       Impact factor: 3.164

9.  Evolving the N-Terminal Domain of Pyrrolysyl-tRNA Synthetase for Improved Incorporation of Noncanonical Amino Acids.

Authors:  Vangmayee Sharma; Yu Zeng; W Wesley Wang; Yuchen Qiao; Yadagiri Kurra; Wenshe R Liu
Journal:  Chembiochem       Date:  2017-11-16       Impact factor: 3.164

10.  Exploring the substrate range of wild-type aminoacyl-tRNA synthetases.

Authors:  Chenguang Fan; Joanne M L Ho; Napon Chirathivat; Dieter Söll; Yane-Shih Wang
Journal:  Chembiochem       Date:  2014-05-30       Impact factor: 3.164
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