| Literature DB >> 21224928 |
Abstract
In order to achieve uniformity in radiological imaging, it is recommended that the concept of equivalence in shape (quality) and size (quantity) of clinical Xray beams should be used for carrying out the comparative evaluation of image and patient dose. When used under the same irradiation geometry, X-ray beams that are strictly or relatively equivalent in terms of shape and size will produce identical or relatively identical image quality and patient dose. Simple mathematical models and software program EQSPECT.FOR were developed for the comparative evaluation of the performance characteristics in terms of contrast (C), contrast to noise ratio (CNR) and figure-of-merit (FOM = CNR(2)/DOSE) for spectrally equivalent beams transmitted through filter materials referred to as conventional and k-edged. At the same value of operating potential (kVp), results show that spectrally equivalent beam transmitted through conventional filter with higher atomic number (Z-value) in comparison with that transmitted through conventional filter with lower Z-value resulted in the same value of C and FOM. However, in comparison with the spectrally equivalent beam transmitted through filter of lower Z-value, the beam through filter of higher Z-value produced higher value of CNR and DOSE at equal tube loading (mAs) and kVp. Under the condition of equivalence of spectrum, at scaled (or reduced) tube loading and same kVp, filter materials of higher Z-value can produce the same values of C, CNR, DOSE and FOM as filter materials of lower Z-value. Unlike the case of comparison of spectrally equivalent beam transmitted through one conventional filter and that through another conventional filter, it is not possible to derive simple mathematical formulations for the relative performance of spectrally equivalent beam transmitted through a given conventional filter material and that through kedge filter material.Entities:
Keywords: Contrast; elemental filters; medical diagnostic radiology
Year: 2007 PMID: 21224928 PMCID: PMC3014103 DOI: 10.4103/0971-6203.37483
Source DB: PubMed Journal: J Med Phys ISSN: 0971-6203
Glossary of terms used in computer simulations and mathematical formulations
| T(tm) | The average transmittance of filter material, m at spectrally equivalent thickness of tm |
| μm(Ei),μw(Ei),μc(Ei) | Attenuation coefficient for filter material, m, water, contrast medium respectively at energy Ei |
| C | Contrast (scatter-free) |
| CAl, CCu | Contrast from beams filtered by aluminum and copper respectively (scatter-free) |
| DOSEAl, DOSECu, DOSEY | Dose from beams filtered by aluminum, copper and yttrium respectively |
| DOSEm, DOSEref | Dose from beams filtered by material, m and reference material respectively |
| CNRAl, CNRCu, CNRY | Contrast-to-noise ratio for beams filtered by aluminum, copper and yttrium respectively |
| CNRm, CNRref | Contrast-to-noise ratio for beams filtered by material, m and reference material respectively |
| Ea, Eb | Photon energy intensity absorbed in the phosphor with and without embedded contrast medium respectively |
| μLi/ρ | Local mass energy transfer coeficient of the phosphor at energy Ei |
| μdi/ρ | Mass attenuation coefficient of the phosphor at energy Ei |
| tw, td, tc | Thickness of water phantom, phosphor and contrast medium respectively |
| FOM | Figure of merit |
| FOMAl, FOMCu, FOMY | Figure of merit for beams filtered by aluminum, copper and yttrium respectively |
| FOMm, FOMref | Figure of merit for beams filtered by material, m and reference material respectively |
| E(tw) | Average energy in joules imparted to water phantom of thickness tw cm by a normally incident monoenergetic photon of energy Ei |
| imax | Maximum value of energy index |
| T | Transmission |
| TAl, TCu, TY, Tm, Tref | Transmission through aluminum, copper, yttrium, material, m and reference filter material respectively |
| mAm, mAref | Tube current for beams filtered by material, m and reference material respectively |
| mAsm, mAsref | Tube loading for beams filtered by material, m and reference material respectively |
| S | Exposure time |
| SAl, SCu, Sm, Sref | Exposure time for beams filtered by aluminum, copper, material, m and reference material respectively |
| HUm, HUref | Heat capacity for beams filtered by material, m and reference material respectively |
| V | Numerical value of kVp |
| ɸAl(Ei) | Photon fluence transmitted by aluminum filter (photon/mm−2) |
| ɸCu(Ei) | Photon fluence transmitted by copper filter (photon/mm−2 ) |
Values of λm resulting in best fit to Eq. (11). r2 gives the range of coefficient of regression
| 12Mg | −1.407940 | −1.428000 | −1.432290 | −1.420970 | −1.414910 | −1.403030 | −1.394460 | −1.400740 | −1.372860 | −1.383940 | 0.9939 - 0.9974 |
| 13Al | −1.097770 | −1.128060 | −1.135200 | −1.133430 | −1.125200 | −1.118910 | −1.111830 | −1.102740 | −1.095260 | −1.092290 | 0.9971 - 0.9992 |
| 14Si | −0.854570 | −0.904057 | −0.905371 | −0.920514 | −0.919143 | −0.919486 | −0.914171 | −0.910571 | −0.905314 | −0.899657 | 0.9958 - 0.9998 |
| 23V | −0.090857 | −0.110857 | −0.119143 | −0.124571 | −0.123943 | −0.125257 | −0.125714 | −0.125943 | −0.124971 | −0.125886 | 0.9890 - 0.9999 |
| 26Fe | 0.012800 | −0.005086 | −0.018514 | −0.024515 | −0.026800 | −0.028343 | −0.030229 | −0.032000 | −0.033029 | −0.032972 | 0.8800 - 0.9957 |
| 28Ni | 0.033372 | 0.021428 | 0.014514 | 0.010000 | 0.005714 | 0.004400 | 0.001930 | 0.000914 | −0.000229 | −0.000286 | 0.8843 - 0.9657 |
| 30Zn | 0.033028 | 0.029257 | 0.026000 | 0.024343 | 0.023486 | 0.021943 | 0.021543 | 0.020571 | 0.020171 | 0.019658 | 0.9969 - 0.9994 |
| 32Ge | 0.013829 | 0.026286 | 0.028857 | 0.029486 | 0.030686 | 0.031143 | 0.030972 | 0.031143 | 0.030686 | 0.030971 | 0.8721 - 0.9994 |
| 39Y | −0.010451 | −0.030800 | 0.003257 | 0.026171 | 0.031771 | 0.036914 | 0.040971 | 0.045771 | 0.047086 | 0.061372 | 0.8998 - 0.9994 |
Comparison of the performance of filters relative to a 0.200-mm Cu filter at ‘spectrally’ equivalent thicknesses
| (i) Aluminum: teq = 7.34 mm Al | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 50 | 7.30 (7.31) | 1.290 | 1.289 | 0.999 | 0.998 | 1.000 | 1.000 | 0.999 | 0.998 | 1.300 | 0.996 | 1.001 |
| 70 | 7.42 (7.42) | 1.318 | 1.318 | 0.999 | 0.997 | 1.000 | 1.000 | 0.999 | 0.997 | 1.311 | 1.001 | 1.002 |
| 100 | 7.45 (7.45) | 1.322 | 1.321 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.312 | 1.001 | 1.001 |
| (ii) Iron: teq = 0.306 mm Fe | ||||||||||||
| 50 | 0.303 (0.305) | 0.992 | 0.992 | 1.000 | 0.999 | 1.000 | 1.000 | 1.000 | 0.999 | 1.000 | 0.997 | 1.000 |
| 70 | 0.305 (0.307) | 1.000 | 1.000 | 0.999 | 0.999 | 1.000 | 1.000 | 0.999 | 0.999 | 1.002 | 1.000 | 1.001 |
| 100 | 0.307 (0.308) | 1.004 | 1.004 | 0.999 | 0.999 | 1.000 | 1.000 | 0.999 | 0.999 | 1.003 | 1.000 | 1.001 |
| (iii) Yttrium: teq = 0.18 mm Y | ||||||||||||
| 50 | 0.188 (0.184) | 1.033 | 1.038 | 1.001 | 1.007 | 0.998 | 1.002 | 1.001 | 1.007 | 0.999 | 1.040 | 1.000 |
| 70 | 0.183 (0.180) | 1.009 | 1.010 | 1.003 | 1.006 | 0.999 | 1.001 | 1.003 | 1.006 | 1.000 | 1.009 | 0.999 |
| 100 | 0.181 (0.177) | 0.998 | 0.999 | 1.003 | 1.005 | 1.000 | 1.000 | 1.003 | 1.005 | 0.997 | 1.002 | 0.998 |
From Table 5 of Nagel[9].
Values obtained by using differential exposure time that will make the beams transmitted through pairs of filter materials to be of the same size (or intensity). Note that teq is slightly dependent on kVp. This increase in exposure time is for filter material with lower Z-value.
Values without brackets are those obtained by using algorithm reported by Jennings[8], and those in brackets are those obtained by using Eqs. (17–18) in this text.
Values of ωn and αn resulting in best fit to Eqs. (17-18). r2 is the coefficient of regression
| ω0 | ω1 | ω2 | ω3 | ω4 | ||
|---|---|---|---|---|---|---|
| 12Mg | 60.5833 | 5.88075E−1 | −7.96244E−3 | 4.67883E−5 | −1.04474E−7 | 0.9949 |
| 13Al | 32.2241 | 1.81886E−1 | −2.16175E−3 | 1.07441E−5 | −1.94637E−8 | 0.9966 |
| 14Si | 24.2750 | 3.68141E−1 | −5.12638E−3 | 3.18642E−5 | −7.45273E−8 | 0.9969 |
| 23V | 2.74584 | 1.02934E−2 | −1.33379E−4 | 7.72564E−7 | −1.66981E−9 | 0.9961 |
| 26Fe | 1.44884 | 2.37010E−3 | −2.12339E−5 | 7.56049E−8 | −6.95810E−8 | 0.9950 |
| 28Ni | 1.03401 | 8.21319E−4 | −7.35967E−6 | 3.24672E−8 | −5.83929E−11 | 0.9979 |
| 30Zn | 1.10266 | 2.31597E−4 | −1.50300E−6 | 2.09495E−9 | 9.63671E−12 | 0.9986 |
| 32Ge | 1.40684 | −3.33777E−3 | 4.75635E−5 | −3.01819E−7 | 7.13212E−10 | 0.9920 |
| 39Y | 1.18781 | −1.02043E−2 | 1.33242E−4 | −7.87023E−7 | 1.74605E−9 | 0.9989 |
| α0 | α1 | α2 | α3 | α4 | ||
| 12Mg | −2.86201E−2 | −1.49630E−2 | 2.87569E−4 | −2.01749E−6 | 5.21297E−9 | 0.9956 |
| 13Al | −1.70680E−1 | 1.80353E−3 | −2.46925E−5 | 2.57028E−7 | 8.76419E−10 | 0.9951 |
| 14Si | 1.83040E−1 | −1.49477E−2 | 2.53103E−4 | −1.75051E−6 | 4.39033E−9 | 0.9893 |
Figure 1Schematic diagram for the implementation of the computer simulations
Main steps in the execution of the computer program EQSPECT.FORa
| The main steps in the execution of the software computer program, EQSPECT.FOR for the evaluation of performance characteristics of elemental filters materials (conventional and k-edge) in medical diagnostics are as follows: | |||
| STEP 1: | Main program: Computes the spectral distribution for a specified operating potential (50-150 kVp) using the algorithms reported by Bonne and Siebert.[ | ||
| Input: (1) kVp (2) ripple factor for X-ray tube; 100 (%) for single phase generators (%) (3) thickness of intensifying screen (mg/cm2) (4) thickness of contrast medium (mg/cm2) (5) type of comparison: spectrally equivalent thickness or arbitrary thickness (6) thickness of reference filter (mm) (7) thickness of alternative filter (if arbitrary) (mm) (8) atomic number of alternative filter. | |||
| STEP 2 | Call EQAL OR EQCU: Computes the thickness of a specified alternative filter material that will generate equivalent spectral (or produce equal hardening/shape) as a specified thickness of aluminum (EQAL) or copper (EQCU) filter. | ||
| STEP 3: | Call MATCH: | (A) | Without scaling of spectral |
| Compute the thickness of an alternative filter material that will produce same hardening as a specified thickness of an arbitrary reference filter material. | |||
| Input data: (1) incident spectral (unfiltered spectral) (2) contrast medium (barium or calcium or iodine) (3) image receptor (assumed ideal, hence absorb all energy: calcium tungstate or cesium iodide or gadolinium oxysulfide). | |||
| Output data: (1) kVp (2) filter thickness (3) ratios of fluence, exposure, kerma, dose, contrast, contrast-to-noise and figure-of-merit for the two filter materials (at ‘spectrally’ equivalent thicknesses. (3) α (4) δ (5) ‘spectrally’ equivalent thickness. | |||
| (B) | Repeat (A) using the factor, α | ||
| (C) | Output: Spectral distributions for (1) unfiltered beam (2) filtered beam (3) transmitted through reference filter (4) transmitted through alternative filter. | ||
The program and the 32 data files that are required for its execution are available for download via http://www4.webng.com/okunade or request via e-mail from the author.
Figure 2Ratios of T, DOSE, [CNR]2, CNR, contrast and FOM for beams transmitted through aluminum/copper filter (denominator) and selected alternative filter materials (numerator) at ‘spectrally’ equivalent thicknesses. This is for intensifying screen of 80 mg/cm−2 Gd2O2S, contrast medium of 10 mg/cm−2 iodine and object of 20 cm thick water phantom. The values of root-mean-square error are less than 1.0% for all cases of matching the hardening of pairs of conventional filters
Figure 3Comparison of the shape and size of transmitted spectral energy distribution at ‘spectrally’ equivalent thicknesses of aluminum and copper filter materials. The spectrals compared are (i) without scaling, ΦAl(Ei) and ΦCu(Ei) and (ii) with scaling, ΦAl(Ei) and aΦCu(Ei)
Figure 4Comparison of the shape and size of transmitted spectral energy distribution at ‘spectrally’ equivalent thicknesses of aluminum/copper and gadolinium filters. The values of the minimum root-mean-square error in the matching of hardening were found to be 24.5% for these aluminum and gadolinium filters and 44.4% for these copper and gadolinium filters. The gadolinium filter transmits more photons at energies below its k-edge than aluminum and copper filters. There is a significant disparity in the hardening and attenuation properties of aluminum/copper (conventional filter) and those of gadolinium (k-edged filter)
Figure 5Ratios of T, DOSE, [CNR]2, CNR, contrast and FOM for beams transmitted through aluminum/copper filter (denominator) and lanthanium filter (numerator) at ‘spectrally’ equivalent thicknesses. This is for intensifying screen of 80 mg/cm−2 Gd2O2S, contrast medium of 10 mg/cm−2 iodine and object of 20 cm thick water phantom. There is a significant difference in both the shape and size of beams transmitted by aluminum/copper and lanthanium filters. Hence ratios of T, DOSE, [CNR]2, CNR, contrast and FOM deviate significantly from unity
Performance characteristics of 0.097 mm Cu filter relative to 0.088 mm Gd filter
| 60 | 1.17 | 1.18 | 1.20 |
| 80 | 1.33 | 1.36 | 1.39 |
| 100 | 1.39 | 1.42 | 1.44 |