BACKGROUND: The effect of gastroesophageal reflux disease (GERD) on health-related quality of life (HRQL) in COPD has never been assessed. AIM: To evaluate HRQL in patients with COPD alone compared with those with both COPD and continuing GERD symptoms. METHODS: A questionnaire-based, cross-sectional survey was performed. Subjects were recruited from the outpatient pulmonary clinics at the University of Florida Health Science Center/Jacksonville. Included patients had an established diagnosis of COPD. Exclusion criteria were respiratory disorders other than COPD, known esophageal disease, active peptic ulcer disease, Zollinger-Ellison syndrome, mastocytosis, scleroderma, and current alcohol abuse. Those meeting the criteria and agreeing to participate were asked to complete the Mayo Clinic GERQ and SF-36 questionnaires, by either personal or telephone interview. Clinically significant reflux was defined as heartburn and/or acid regurgitation weekly. Study patients were divided into two groups for HRQL analysis based on the GERQ response: COPD+/GERD+ and COPD only. Statistical analysis was performed using the Mann-Whitney-Wilcoxon T test for unequal variables and linear regression was performed using ANOVA. All data are expressed as mean and standard deviation. RESULTS: Eighty-six patients completed both questionnaires. Males were 55% and COPD+/GERD+ patients comprised 37% of the study group. Compared with COPD only, HRQL was reduced across all measures for the COPD+ GERD+ patients and achieved significance for bodily pain (P < 0.02), mental health (P < 0.05), and physical component score (P < 0.05). CONCLUSION: Patients with COPD and continuing GERD symptoms have reduced HRQL in comparison with those with COPD alone.
BACKGROUND: The effect of gastroesophageal reflux disease (GERD) on health-related quality of life (HRQL) in COPD has never been assessed. AIM: To evaluate HRQL in patients with COPD alone compared with those with both COPD and continuing GERD symptoms. METHODS: A questionnaire-based, cross-sectional survey was performed. Subjects were recruited from the outpatient pulmonary clinics at the University of Florida Health Science Center/Jacksonville. Included patients had an established diagnosis of COPD. Exclusion criteria were respiratory disorders other than COPD, known esophageal disease, active peptic ulcer disease, Zollinger-Ellison syndrome, mastocytosis, scleroderma, and current alcohol abuse. Those meeting the criteria and agreeing to participate were asked to complete the Mayo Clinic GERQ and SF-36 questionnaires, by either personal or telephone interview. Clinically significant reflux was defined as heartburn and/or acid regurgitation weekly. Study patients were divided into two groups for HRQL analysis based on the GERQ response: COPD+/GERD+ and COPD only. Statistical analysis was performed using the Mann-Whitney-Wilcoxon T test for unequal variables and linear regression was performed using ANOVA. All data are expressed as mean and standard deviation. RESULTS: Eighty-six patients completed both questionnaires. Males were 55% and COPD+/GERD+ patients comprised 37% of the study group. Compared with COPD only, HRQL was reduced across all measures for the COPD+ GERD+ patients and achieved significance for bodily pain (P < 0.02), mental health (P < 0.05), and physical component score (P < 0.05). CONCLUSION:Patients with COPD and continuing GERD symptoms have reduced HRQL in comparison with those with COPD alone.
Authors: Wai-Man Wong; Sara Risner-Adler; Joy Beeler; Sara Habib; Jimmy Bautista; Steven Goldman; Ronnie Fass Journal: J Clin Gastroenterol Date: 2005 Nov-Dec Impact factor: 3.062
Authors: Peter J Kahrilas; Nicholas J Shaheen; Michael F Vaezi; Stephen W Hiltz; Edgar Black; Irvin M Modlin; Steve P Johnson; John Allen; Joel V Brill Journal: Gastroenterology Date: 2008-10 Impact factor: 22.682
Authors: C Casanova; J S Baudet; M del Valle Velasco; J M Martin; A Aguirre-Jaime; J P de Torres; J Pablo de Torres; B R Celli Journal: Eur Respir J Date: 2004-06 Impact factor: 16.671
Authors: Eléonore F van Dam van Isselt; Karin H Groenewegen-Sipkema; Monica Spruit-van Eijk; Niels H Chavannes; Margot W M de Waal; Daisy J A Janssen; Wilco P Achterberg Journal: BMJ Open Date: 2014-09-26 Impact factor: 2.692
Authors: Carlos H Martinez; Yuka Okajima; Susan Murray; George R Washko; Fernando J Martinez; Edwin K Silverman; Jin Hwa Lee; Elizabeth A Regan; James D Crapo; Jeffrey L Curtis; Hiroto Hatabu; MeiLan K Han Journal: Respir Res Date: 2014-06-03