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Literature DB >> 2121718

Role of the far-upstream sites of the algD promoter and the algR and rpoN genes in environmental modulation of mucoidy in Pseudomonas aeruginosa.

C D Mohr¹, D W Martin, W M Konyecsni, J R Govan, S Lory, V Deretic.

Abstract

The role of several regulatory elements in environmental modulation of mucoidy in Pseudomonas aeruginosa was studied. Transcriptional activation of algD, necessary for the mucoid phenotype, was found to depend on FUS, the newly identified far-upstream sites of the algD promoter. The FUS were delimited to a region spanning nucleotides -432 to -332 relative to the algD mRNA start site. Insertional inactivation of algR in PAO568 abolished the algD promoter response to nitrogen availability and greatly diminished but did not completely eliminate reactivity to changes in salt concentration. Insertional inactivation of rpoN (ntrA) in PAO568 did not affect algR and algD transcription.

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Year: 1990 PMID： 2121718 PMCID： PMC526848 DOI： 10.1128/jb.172.11.6576-6580.1990

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

22 in total

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7. Pseudomonas aeruginosa AlgR phosphorylation modulates rhamnolipid production and motility.

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10. Gene cluster controlling conversion to alginate-overproducing phenotype in Pseudomonas aeruginosa: functional analysis in a heterologous host and role in the instability of mucoidy.

Authors: M J Schurr; D W Martin; M H Mudd; V Deretic
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