Literature DB >> 3088280

Transfer of a chromosomal locus responsible for mucoid colony morphology in Pseudomonas aeruginosa isolated from cystic fibrosis patients to P. aeruginosa PAO.

J MacGeorge, V Korolik, A F Morgan, V Asche, B W Holloway.   

Abstract

The locus responsible for mucoid colony morphology in five independent clinical isolates of Pseudomonas aeruginosa from cystic fibrosis patients have been transferred by means of pM060-mediated conjugation to the genetically characterised strain P. aeruginosa PAO. Genetic mapping has shown that in all five strains the locus is on the chromosome between 89' and 94', although it is not possible to say that the same locus is involved in each case. The way is now open for a more detailed genetic analysis of the loci responsible for mucoid colony morphology.

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Year:  1986        PMID： 3088280     DOI： 10.1099/00222615-21-4-331

Source DB:  PubMed          Journal:  J Med Microbiol        ISSN： 0022-2615            Impact factor:   2.472


  22 in total

1.  Role of the far-upstream sites of the algD promoter and the algR and rpoN genes in environmental modulation of mucoidy in Pseudomonas aeruginosa.

Authors:  C D Mohr; D W Martin; W M Konyecsni; J R Govan; S Lory; V Deretic
Journal:  J Bacteriol       Date:  1990-11       Impact factor: 3.490

2.  AlgR, a response regulator controlling mucoidy in Pseudomonas aeruginosa, binds to the FUS sites of the algD promoter located unusually far upstream from the mRNA start site.

Authors:  C D Mohr; N S Hibler; V Deretic
Journal:  J Bacteriol       Date:  1991-08       Impact factor: 3.490

3.  Cloning of genes from mucoid Pseudomonas aeruginosa which control spontaneous conversion to the alginate production phenotype.

Authors:  J L Flynn; D E Ohman
Journal:  J Bacteriol       Date:  1988-04       Impact factor: 3.490

4.  DNA sequence and expression analysis of algP and algQ, components of the multigene system transcriptionally regulating mucoidy in Pseudomonas aeruginosa: algP contains multiple direct repeats.

Authors:  W M Konyecsni; V Deretic
Journal:  J Bacteriol       Date:  1990-05       Impact factor: 3.490

Review 5.  Conversion of Pseudomonas aeruginosa to mucoidy in cystic fibrosis: environmental stress and regulation of bacterial virulence by alternative sigma factors.

Authors:  V Deretic; M J Schurr; J C Boucher; D W Martin
Journal:  J Bacteriol       Date:  1994-05       Impact factor: 3.490

Review 6.  Microbiology of airway disease in patients with cystic fibrosis.

Authors:  P H Gilligan
Journal:  Clin Microbiol Rev       Date:  1991-01       Impact factor: 26.132

Review 7.  Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia.

Authors:  J R Govan; V Deretic
Journal:  Microbiol Rev       Date:  1996-09

8.  Characterization of a locus determining the mucoid status of Pseudomonas aeruginosa: AlgU shows sequence similarities with a Bacillus sigma factor.

Authors:  D W Martin; B W Holloway; V Deretic
Journal:  J Bacteriol       Date:  1993-02       Impact factor: 3.490

9.  Transcriptional analysis of the Pseudomonas aeruginosa genes algR, algB, and algD reveals a hierarchy of alginate gene expression which is modulated by algT.

Authors:  D J Wozniak; D E Ohman
Journal:  J Bacteriol       Date:  1994-10       Impact factor: 3.490

10.  Functional equivalence of Escherichia coli sigma E and Pseudomonas aeruginosa AlgU: E. coli rpoE restores mucoidy and reduces sensitivity to reactive oxygen intermediates in algU mutants of P. aeruginosa.

Authors:  H Yu; M J Schurr; V Deretic
Journal:  J Bacteriol       Date:  1995-06       Impact factor: 3.490
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