| Literature DB >> 21215938 |
David del Álamo1, Hervé Rouault, François Schweisguth.
Abstract
Notch receptors in a given cell are activated by cell surface ligands in neighbouring cells but can also be inhibited by the ligands present within the same cell. This process is known as cis-inhibition of Notch. Additionally, reciprocal cis-inhibition of the ligands by Notch has also been observed, albeit to a limited extent. Here, we review the mechanisms, functional relevance and potential implications of these cis-inhibitory interactions for Notch-mediated fate decisions.Mesh：
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Year: 2011 PMID： 21215938 DOI： 10.1016/j.cub.2010.10.034
Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834