| Literature DB >> 21215366 |
Reini F Luco1, Mariano Allo, Ignacio E Schor, Alberto R Kornblihtt, Tom Misteli.
Abstract
Alternative splicing plays critical roles in differentiation, development, and disease and is a major source for protein diversity in higher eukaryotes. Analysis of alternative splicing regulation has traditionally focused on RNA sequence elements and their associated splicing factors, but recent provocative studies point to a key function of chromatin structure and histone modifications in alternative splicing regulation. These insights suggest that epigenetic regulation determines not only what parts of the genome are expressed but also how they are spliced. Copyright ÂEntities:
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Year: 2011 PMID： 21215366 PMCID： PMC3038581 DOI： 10.1016/j.cell.2010.11.056
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582