| Literature DB >> 22172665 |
Bruce A Hamilton1, Xiang-Dong Fu.
Abstract
Are all introns spliced cotranscriptionally? In a recent issue of Cell, Vargas et al. (2011) reported single-molecule analyses of pre-mRNA splicing, confirming transcription-coupled splicing of constitutive introns but finding off-site and delayed splicing of alternative introns. The results raise the question of whether kinetics distinguishes constitutive from regulated splicing.Entities:
Year: 2011 PMID: 22172665 PMCID: PMC4442631 DOI: 10.1016/j.devcel.2011.11.010
Source DB: PubMed Journal: Dev Cell ISSN: 1534-5807 Impact factor: 12.270