Literature DB >> 21212233

Genetic evidence that DNA methyltransferase DRM2 has a direct catalytic role in RNA-directed DNA methylation in Arabidopsis thaliana.

Ulf Naumann1, Lucia Daxinger, Tatsuo Kanno, Changho Eun, Quan Long, Zdravko J Lorkovic, Marjori Matzke, Antonius J M Matzke.   

Abstract

RNA-directed DNA methylation (RdDM) is a small RNA-mediated epigenetic modification in plants. We report here the identification of DOMAINS REARRANGED METHYLTRANSFERASE 2 (DRM2) in a forward screen for mutants defective in RdDM in Arabidopsis thaliana. The finding of a mutation in the presumptive active site argues in favor of direct catalytic activity for DRM2.
© 2011 by the Genetics Society of America

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Year:  2011        PMID： 21212233      PMCID： PMC3048785          DOI： 10.1534/genetics.110.125401

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  14 in total

1.  Conserved plant genes with similarity to mammalian de novo DNA methyltransferases.

Authors:  X Cao; N M Springer; M G Muszynski; R L Phillips; S Kaeppler; S E Jacobsen
Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-25       Impact factor: 11.205

2.  Role of the DRM and CMT3 methyltransferases in RNA-directed DNA methylation.

Authors:  Xiaofeng Cao; Werner Aufsatz; Daniel Zilberman; M Florian Mette; Michael S Huang; Marjori Matzke; Steven E Jacobsen
Journal:  Curr Biol       Date:  2003-12-16       Impact factor: 10.834

3.  A stepwise pathway for biogenesis of 24-nt secondary siRNAs and spreading of DNA methylation.

Authors:  Lucia Daxinger; Tatsuo Kanno; Etienne Bucher; Johannes van der Winden; Ulf Naumann; Antonius J M Matzke; Marjori Matzke
Journal:  EMBO J       Date:  2008-12-11       Impact factor: 11.598

4.  A structural-maintenance-of-chromosomes hinge domain-containing protein is required for RNA-directed DNA methylation.

Authors:  Tatsuo Kanno; Etienne Bucher; Lucia Daxinger; Bruno Huettel; Gudrun Böhmdorfer; Wolfgang Gregor; David P Kreil; Marjori Matzke; Antonius J M Matzke
Journal:  Nat Genet       Date:  2008-04-20       Impact factor: 38.330

5.  Biological functions of DNA methyltransferase 1 require its methyltransferase activity.

Authors:  Marc Damelin; Timothy H Bestor
Journal:  Mol Cell Biol       Date:  2007-03-19       Impact factor: 4.272

Review 6.  Establishing, maintaining and modifying DNA methylation patterns in plants and animals.

Authors:  Julie A Law; Steven E Jacobsen
Journal:  Nat Rev Genet       Date:  2010-03       Impact factor: 53.242

7.  Rapid array mapping of circadian clock and developmental mutations in Arabidopsis.

Authors:  Samuel P Hazen; Justin O Borevitz; Frank G Harmon; Jose L Pruneda-Paz; Thomas F Schultz; Marcelo J Yanovsky; Sarah J Liljegren; Joseph R Ecker; Steve A Kay
Journal:  Plant Physiol       Date:  2005-05-20       Impact factor: 8.340

8.  Role of the arabidopsis DRM methyltransferases in de novo DNA methylation and gene silencing.

Authors:  Xiaofeng Cao; Steven E Jacobsen
Journal:  Curr Biol       Date:  2002-07-09       Impact factor: 10.834

9.  A procedure for mapping Arabidopsis mutations using co-dominant ecotype-specific PCR-based markers.

Authors:  A Konieczny; F M Ausubel
Journal:  Plant J       Date:  1993-08       Impact factor: 6.417

Review 10.  Structure and function of DNA methyltransferases.

Authors:  X Cheng
Journal:  Annu Rev Biophys Biomol Struct       Date:  1995
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  18 in total

1.  An atypical component of RNA-directed DNA methylation machinery has both DNA methylation-dependent and -independent roles in locus-specific transcriptional gene silencing.

Authors:  Jun Liu; Ge Bai; Cuijun Zhang; Wei Chen; Jinxing Zhou; Suwei Zhang; Qing Chen; Xin Deng; Xin-Jian He; Jian-Kang Zhu
Journal:  Cell Res       Date:  2011-11-08       Impact factor: 25.617

Review 2.  Connecting the dots of RNA-directed DNA methylation in Arabidopsis thaliana.

Authors:  Pedro Costa-Nunes; Alexa Vitins; Olga Pontes
Journal:  Chromosome Res       Date:  2014-06       Impact factor: 5.239

Review 3.  RNA-directed DNA methylation: an epigenetic pathway of increasing complexity.

Authors:  Marjori A Matzke; Rebecca A Mosher
Journal:  Nat Rev Genet       Date:  2014-05-08       Impact factor: 53.242

4.  Identification and expression profiling of DNA methyltransferases during development and stress conditions in Solanaceae.

Authors:  Rahul Kumar; Pankaj Kumar Chauhan; Ashima Khurana
Journal:  Funct Integr Genomics       Date:  2016-07-05       Impact factor: 3.410

5.  Atypical DNA methylation of genes encoding cysteine-rich peptides in Arabidopsis thaliana.

Authors:  Wanhui You; Agata Tyczewska; Matthew Spencer; Lucia Daxinger; Marc W Schmid; Ueli Grossniklaus; Stacey A Simon; Blake C Meyers; Antonius J M Matzke; Marjori Matzke
Journal:  BMC Plant Biol       Date:  2012-04-19       Impact factor: 4.215

6.  IDN2 has a role downstream of siRNA formation in RNA-directed DNA methylation.

Authors:  Andreas Finke; Markus Kuhlmann; Michael Florian Mette
Journal:  Epigenetics       Date:  2012-07-19       Impact factor: 4.528

7.  AGO6 functions in RNA-mediated transcriptional gene silencing in shoot and root meristems in Arabidopsis thaliana.

Authors:  Changho Eun; Zdravko J Lorkovic; Ulf Naumann; Quan Long; Ericka R Havecker; Stacey A Simon; Blake C Meyers; Antonius J M Matzke; Marjori Matzke
Journal:  PLoS One       Date:  2011-10-05       Impact factor: 3.240

8.  In Posidonia oceanica cadmium induces changes in DNA methylation and chromatin patterning.

Authors:  Maria Greco; Adriana Chiappetta; Leonardo Bruno; Maria Beatrice Bitonti
Journal:  J Exp Bot       Date:  2011-11-04       Impact factor: 6.992

9.  Involvement of MEM1 in DNA demethylation in Arabidopsis.

Authors:  Yanke Lu; Jie Dai; Liu Yang; Yumei La; Shaoxia Zhou; Sheng Qiang; Qianqian Wang; Feng Tan; Yufeng Wu; Weiwen Kong; Honggui La
Journal:  Plant Mol Biol       Date:  2020-01-04       Impact factor: 4.076

10.  IDN2 and its paralogs form a complex required for RNA-directed DNA methylation.

Authors:  Cui-Jun Zhang; Yong-Qiang Ning; Su-Wei Zhang; Qing Chen; Chang-Rong Shao; Yan-Wu Guo; Jin-Xing Zhou; Lin Li; She Chen; Xin-Jian He
Journal:  PLoS Genet       Date:  2012-05-03       Impact factor: 5.917
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