Literature DB >> 22549588

Bisindoylmaleimide I enhances osteogenic differentiation.

Fangfang Zhou1, Huizhe Huang, Long Zhang.   

Abstract

The Wnt/β-catenin and bone morphogenetic proteins (BMPs) pathways play important roles in controlling osteogenesis. Using a cell-based kinase inhibitor screening assay, we identified the compound bisindoylmaleimide I (BIM) as a potent agonist of the cytosolic β-catenin accumulation in preosteoblast cells. Through suppressing glycogen synthase kinase 3β enzyme activities, BIM upregulated β-catenin responsive transcription and extended duration of BMP initiated signal. Functional analysis revealed that BIM promoted osteoblast differentiation and bone formation. The treatment of human mesenchymal stem cells with BIM promoted osteoblastogenesis. Our findings provide a new strategy to regulate mesenchymal stem cell differentiation by integration of the cellular signaling pathways.

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Year:  2012        PMID： 22549588      PMCID： PMC4875475          DOI： 10.1007/s13238-012-2027-4

Source DB:  PubMed          Journal:  Protein Cell        ISSN： 1674-800X            Impact factor:   14.870


  42 in total

1.  Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation.

Authors:  Donald A Glass; Peter Bialek; Jong Deok Ahn; Michael Starbuck; Millan S Patel; Hans Clevers; Mark M Taketo; Fanxin Long; Andrew P McMahon; Richard A Lang; Gerard Karsenty
Journal:  Dev Cell       Date:  2005-05       Impact factor: 12.270

2.  Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal.

Authors:  Luis C Fuentealba; Edward Eivers; Atsushi Ikeda; Cecilia Hurtado; Hiroki Kuroda; Edgar M Pera; Edward M De Robertis
Journal:  Cell       Date:  2007-11-30       Impact factor: 41.582

3.  LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.

Authors:  Y Gong; R B Slee; N Fukai; G Rawadi; S Roman-Roman; A M Reginato; H Wang; T Cundy; F H Glorieux; D Lev; M Zacharin; K Oexle; J Marcelino; W Suwairi; S Heeger; G Sabatakos; S Apte; W N Adkins; J Allgrove; M Arslan-Kirchner; J A Batch; P Beighton; G C Black; R G Boles; L M Boon; C Borrone; H G Brunner; G F Carle; B Dallapiccola; A De Paepe; B Floege; M L Halfhide; B Hall; R C Hennekam; T Hirose; A Jans; H Jüppner; C A Kim; K Keppler-Noreuil; A Kohlschuetter; D LaCombe; M Lambert; E Lemyre; T Letteboer; L Peltonen; R S Ramesar; M Romanengo; H Somer; E Steichen-Gersdorf; B Steinmann; B Sullivan; A Superti-Furga; W Swoboda; M J van den Boogaard; W Van Hul; M Vikkula; M Votruba; B Zabel; T Garcia; R Baron; B R Olsen; M L Warman
Journal:  Cell       Date:  2001-11-16       Impact factor: 41.582

4.  Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.

Authors:  V Korinek; N Barker; P J Morin; D van Wichen; R de Weger; K W Kinzler; B Vogelstein; H Clevers
Journal:  Science       Date:  1997-03-21       Impact factor: 47.728

5.  Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation.

Authors:  Long Zhang; Xia Gao; Jun Wen; Yuanheng Ning; Ye-Guang Chen
Journal:  J Biol Chem       Date:  2006-01-30       Impact factor: 5.157

Review 6.  BMP-6 and mesenchymal stem cell differentiation.

Authors:  Slobodan Vukicevic; Lovorka Grgurevic
Journal:  Cytokine Growth Factor Rev       Date:  2009-11-08       Impact factor: 7.638

7.  Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma.

Authors:  Ya-Wei Qiang; Bart Barlogie; Stuart Rudikoff; John D Shaughnessy
Journal:  Bone       Date:  2007-12-27       Impact factor: 4.398

8.  Fas-associated factor 1 antagonizes Wnt signaling by promoting β-catenin degradation.

Authors:  Long Zhang; Fangfang Zhou; Theo van Laar; Juan Zhang; Hans van Dam; Peter Ten Dijke
Journal:  Mol Biol Cell       Date:  2011-03-16       Impact factor: 4.138

9.  PDZRN3 negatively regulates BMP-2-induced osteoblast differentiation through inhibition of Wnt signaling.

Authors:  Takeshi Honda; Hisato Yamamoto; Aiko Ishii; Makoto Inui
Journal:  Mol Biol Cell       Date:  2010-07-28       Impact factor: 4.138

10.  BMP-9-induced osteogenic differentiation of mesenchymal progenitors requires functional canonical Wnt/beta-catenin signalling.

Authors:  Ni Tang; Wen-Xin Song; Jinyong Luo; Xiaoji Luo; Jin Chen; Katie A Sharff; Yang Bi; Bai-Cheng He; Jia-Yi Huang; Gao-Hui Zhu; Yu-Xi Su; Wei Jiang; Min Tang; Yun He; Yi Wang; Liang Chen; Guo-Wei Zuo; Jikun Shen; Xiaochuan Pan; Russell R Reid; Hue H Luu; Rex C Haydon; Tong-Chuan He
Journal:  J Cell Mol Med       Date:  2008-11-03       Impact factor: 5.295
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  4 in total

1.  Suppression of GSK3β by ERK mediates lipopolysaccharide induced cell migration in macrophage through β-catenin signaling.

Authors:  Kai Gong; Fangfang Zhou; Huizhe Huang; Yandao Gong; Long Zhang
Journal:  Protein Cell       Date:  2012-09-15       Impact factor: 14.870

2.  Fas-associated factor 1 is a scaffold protein that promotes β-transducin repeat-containing protein (β-TrCP)-mediated β-catenin ubiquitination and degradation.

Authors:  Long Zhang; Fangfang Zhou; Yihao Li; Yvette Drabsch; Juan Zhang; Hans van Dam; Peter ten Dijke
Journal:  J Biol Chem       Date:  2012-06-22       Impact factor: 5.157

3.  Influence of electromagnetic waves, with maxima in the green or red range, on the morphofunctional properties of multipotent stem cells.

Authors:  A S Chernov; D A Reshetnikov; G K Ristsov; Yu A Kovalitskaya; A M Ermakov; A A Manokhin; A V Simakin; R G Vasilov; S V Gudkov
Journal:  J Biol Phys       Date:  2019-10-08       Impact factor: 1.365

4.  The GSK3β inhibitor BIS I reverts YAP-dependent EMT signature in PDAC cell lines by decreasing SMADs expression level.

Authors:  Natthakan Thongon; Ilaria Castiglioni; Chiara Zucal; Elisa Latorre; Vito D'Agostino; Inga Bauer; Michael Pancher; Alberto Ballestrero; Georg Feldmann; Alessio Nencioni; Alessandro Provenzani
Journal:  Oncotarget       Date:  2016-05-03
  4 in total

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