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Literature DB >> 22983902

Suppression of GSK3β by ERK mediates lipopolysaccharide induced cell migration in macrophage through β-catenin signaling.

Kai Gong¹, Fangfang Zhou, Huizhe Huang, Yandao Gong, Long Zhang.

Abstract

We investigate the role of β-catenin signaling in the response of macrophage to lipopolysaccharide (LPS) using RAW264.7 cells. LPS rapidly stimulated cytosolic β-catenin accumulation. β-catenin-mediated transcription was showed to be required for LPS induced gene expression and cell migration. Mechanically, ERK activation-primed GSK3β inactivation by Akt was demonstrated to mediate the LPS induced β-catenin accumulation. Overall, our findings suggest that suppression of GSK3β by ERK stimulates β-catenin signaling therefore contributes to LPS induced cell migration in macrophage activation.

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Year: 2012 PMID： 22983902 PMCID： PMC4875346 DOI： 10.1007/s13238-012-2058-x

Source DB: PubMed Journal: Protein Cell ISSN： 1674-800X Impact factor: 14.870

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