Literature DB >> 21198210

Quantification of in vivo fluorescence decoupled from the effects of tissue optical properties using fiber-optic spectroscopy measurements.

Anthony Kim1, Mamta Khurana, Yumi Moriyama, Brian C Wilson.   

Abstract

We present a method for tissue fluorescence quantification in situ using a handheld fiber optic probe that measures both the fluorescence and diffuse reflectance spectra. A simplified method to decouple the fluorescence spectrum from distorting effects of the tissue optical absorption and scattering is developed, with the objective of accurately quantifying the fluorescence in absolute units. The primary motivation is measurement of 5-aminolevulinic acid-induced protoporphyrin IX (ALA-PpIX) concentration in tissue during fluorescence-guided resection of malignant brain tumors. This technique is validated in phantoms and ex vivo mouse tissues, and tested in vivo in a rabbit brain tumor model using ALA-PpIX fluorescence contrast.

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Year:  2010        PMID： 21198210      PMCID： PMC3025598          DOI： 10.1117/1.3523616

Source DB:  PubMed          Journal:  J Biomed Opt        ISSN： 1083-3668            Impact factor:   3.170


  19 in total

1.  Analytical model for extracting intrinsic fluorescence in turbid media.

Authors:  J Wu; M S Feld; R P Rava
Journal:  Appl Opt       Date:  1993-07-01       Impact factor: 1.980

2.  Scattering and absorption of turbid materials determined from reflection measurements. 1: theory.

Authors:  R A Groenhuis; H A Ferwerda; J J Ten Bosch
Journal:  Appl Opt       Date:  1983-08-15       Impact factor: 1.980

3.  Intrinsic fluorescence spectroscopy in turbid media: disentangling effects of scattering and absorption.

Authors:  M G Müller; I Georgakoudi; Q Zhang; J Wu; M S Feld
Journal:  Appl Opt       Date:  2001-09-01       Impact factor: 1.980

4.  Imaging of glioma tumor with endogenous fluorescence tomography.

Authors:  Dax S Kepshire; Summer L Gibbs-Strauss; Summer L Gibbs-Struass; Julia A O'Hara; Michael Hutchins; Niculae Mincu; Frederic Leblond; Mario Khayat; Hamid Dehghani; Subhadra Srinivasan; Brian W Pogue
Journal:  J Biomed Opt       Date:  2009 May-Jun       Impact factor: 3.170

Review 5.  Light distributions from point, line and plane sources for photochemical reactions and fluorescence in turbid biological tissues.

Authors:  S L Jacques
Journal:  Photochem Photobiol       Date:  1998-01       Impact factor: 3.421

6.  Interstitial fluorescence spectroscopy in the human prostate during motexafin lutetium-mediated photodynamic therapy.

Authors:  Jarod C Finlay; Timothy C Zhu; Andreea Dimofte; Diana Stripp; S Bruce Malkowicz; Theresa M Busch; Stephen M Hahn
Journal:  Photochem Photobiol       Date:  2006 Sep-Oct       Impact factor: 3.421

7.  Fluorescence-guided surgery with 5-aminolevulinic acid for resection of malignant glioma: a randomised controlled multicentre phase III trial.

Authors:  Walter Stummer; Uwe Pichlmeier; Thomas Meinel; Otmar Dieter Wiestler; Friedhelm Zanella; Hans-Jürgen Reulen
Journal:  Lancet Oncol       Date:  2006-05       Impact factor: 41.316

8.  Pharmacokinetics of 5-aminolevulinic-acid-induced porphyrins in tumour-bearing mice.

Authors:  R Sroka; W Beyer; L Gossner; T Sassy; S Stocker; R Baumgartner
Journal:  J Photochem Photobiol B       Date:  1996-06       Impact factor: 6.252

9.  Pharmacology of protoporphyrin IX in nude mice after application of ALA and ALA esters.

Authors:  Johan Moan; Li-Wei Ma; Asta Juzeniene; Vladimir Iani; Petras Juzenas; Fabio Apricena; Qian Peng
Journal:  Int J Cancer       Date:  2003-01-01       Impact factor: 7.396

10.  ALA and Photofrin fluorescence-guided resection and repetitive PDT in glioblastoma multiforme: a single centre Phase III randomised controlled trial.

Authors:  M Sam Eljamel; Carol Goodman; Harry Moseley
Journal:  Lasers Med Sci       Date:  2007-10-10       Impact factor: 3.161
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  64 in total

1.  A spectrally constrained dual-band normalization technique for protoporphyrin IX quantification in fluorescence-guided surgery.

Authors:  P A Valdés; F Leblond; A Kim; B C Wilson; K D Paulsen; D W Roberts
Journal:  Opt Lett       Date:  2012-06-01       Impact factor: 3.776

2.  Quantitative spatial frequency fluorescence imaging in the sub-diffusive domain for image-guided glioma resection.

Authors:  Mira Sibai; Israel Veilleux; Jonathan T Elliott; Frederic Leblond; Brian C Wilson
Journal:  Biomed Opt Express       Date:  2015-11-19       Impact factor: 3.732

3.  Experimental recovery of intrinsic fluorescence and fluorophore concentration in the presence of hemoglobin: spectral effect of scattering and absorption on fluorescence.

Authors:  Vinh Nguyen Du Le; Michael S Patterson; Thomas J Farrell; Joseph E Hayward; Qiyin Fang
Journal:  J Biomed Opt       Date:  2015       Impact factor: 3.170

4.  Accelerated rescaling of single Monte Carlo simulation runs with the Graphics Processing Unit (GPU).

Authors:  Owen Yang; Bernard Choi
Journal:  Biomed Opt Express       Date:  2013-10-29       Impact factor: 3.732

5.  Pixel-based absorption correction for dual-tracer fluorescence imaging of receptor binding potential.

Authors:  Stephen C Kanick; Kenneth M Tichauer; Jason Gunn; Kimberley S Samkoe; Brian W Pogue
Journal:  Biomed Opt Express       Date:  2014-08-29       Impact factor: 3.732

6.  Macroscopic optical imaging technique for wide-field estimation of fluorescence depth in optically turbid media for application in brain tumor surgical guidance.

Authors:  Kolbein K Kolste; Stephen C Kanick; Pablo A Valdés; Michael Jermyn; Brian C Wilson; David W Roberts; Keith D Paulsen; Frederic Leblond
Journal:  J Biomed Opt       Date:  2015-02       Impact factor: 3.170

7.  Early biomarker for radiation-induced wounds: day one post-irradiation assessment using hemoglobin concentration measured from diffuse optical reflectance spectroscopy.

Authors:  Lee C L Chin; Elina K Cook; Darren Yohan; Anthony Kim; Carolyn Niu; Brian C Wilson; Stanley K Liu
Journal:  Biomed Opt Express       Date:  2017-02-21       Impact factor: 3.732

8.  Correcting for targeted and control agent signal differences in paired-agent molecular imaging of cancer cell-surface receptors.

Authors:  Negar Sadeghipour; Scott C Davis; Kenneth M Tichauer
Journal:  J Biomed Opt       Date:  2018-06       Impact factor: 3.170

Review 9.  5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery.

Authors:  Pablo A Valdes; Matthias Millesi; Georg Widhalm; David W Roberts
Journal:  J Neurooncol       Date:  2019-01-02       Impact factor: 4.130

10.  Optical glucose analogs of aminolevulinic acid for fluorescence-guided tumor resection and photodynamic therapy.

Authors:  Eduardo H Moriyama; Weiguo Cao; Tracy W Liu; Han Lin Wang; Peter D Kim; Juan Chen; Gang Zheng; Brian C Wilson
Journal:  Mol Imaging Biol       Date:  2014-08       Impact factor: 3.488
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