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Literature DB >> 21178457

Subcellular localization of the alphaherpesvirus serine/threonine kinase Us3 as a determinant of Us3 function.

Abstract

The Us3 serine threonine kinases perform multiple roles in alphaherpesvirus infection and can localize to distinct subcellular compartments. Transient expression of Us3 in cells results in two dramatic alterations of the actin cytoskeleton: production of actin-based filamentous processes (FPs); and breakdown of actin stress fibres giving rise to rounded cell morphology. In our recent study on FPs induced by HSV-2 Us3, we noted that FP formation was diminished when HSV-2 Us3 was trapped within the nucleus following treatment of transfected cells with leptomycin B (LMB). This observation suggested that subcellular localization of Us3 could be a determinant of Us3-induced FP formation. Here, we review what is known regarding the effect of subcellular localization of Us3 on FP production and on actin stress fibre breakdown and discuss the potential significance of studies aimed at defining the requirements for subcellular localization of Us3.

Entities: Chemical Disease Species

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Year: 2010 PMID： 21178457 PMCID： PMC3073296 DOI： 10.4161/viru.1.4.11980

Source DB: PubMed Journal: Virulence ISSN： 2150-5594 Impact factor: 5.882

40 in total

1. US3 protein kinase of herpes simplex virus protects primary afferent neurons from virus-induced apoptosis in ICR mice.

Authors: S Asano; T Honda; F Goshima; Y Nishiyama; Y Sugiura
Journal: Neurosci Lett Date: 2000-11-17 Impact factor: 3.046

2. The US3 protein kinase of herpes simplex virus 1 mediates the posttranslational modification of BAD and prevents BAD-induced programmed cell death in the absence of other viral proteins.

Authors: J Munger; B Roizman
Journal: Proc Natl Acad Sci U S A Date: 2001-08-21 Impact factor: 11.205

3. Ultrastructural localization of the herpes simplex virus type 1 UL31, UL34, and US3 proteins suggests specific roles in primary envelopment and egress of nucleocapsids.

Authors: Ashley E Reynolds; Elizabeth G Wills; Richard J Roller; Brent J Ryckman; Joel D Baines
Journal: J Virol Date: 2002-09 Impact factor: 5.103

4. US3 protein kinase of herpes simplex virus type 2 plays a role in protecting corneal epithelial cells from apoptosis in infected mice.

Authors: S Asano; T Honda; F Goshima; D Watanabe; Y Miyake; Y Sugiura; Y Nishiyama
Journal: J Gen Virol Date: 1999-01 Impact factor: 3.891

5. Temporary disturbance of actin stress fibers in swine kidney cells during pseudorabies virus infection.

Authors: G Van Minnebruggen; G R Van de Walle; H W Favoreel; H J Nauwynck; M B Pensaert
Journal: Vet Microbiol Date: 2002-04-22 Impact factor: 3.293

6. Antiapoptotic activity of herpes simplex virus type 2: the role of US3 protein kinase gene.

Authors: S Hata; A H Koyama; H Shiota; A Adachi; F Goshima; Y Nishiyama
Journal: Microbes Infect Date: 1999-07 Impact factor: 2.700

7. Effect of the deletion of US2 and US3 from herpes simplex virus type 2 on immune responses in the murine vagina following intravaginal infection.

Authors: K Inagaki-Ohara; T Iwasaki; D Watanabe; T Kurata; Y Nishiyama
Journal: Vaccine Date: 2001-10-12 Impact factor: 3.641

8. Insertions in the gG gene of pseudorabies virus reduce expression of the upstream Us3 protein and inhibit cell-to-cell spread of virus infection.

Authors: G L Demmin; A C Clase; J A Randall; L W Enquist; B W Banfield
Journal: J Virol Date: 2001-11 Impact factor: 5.103

9. Expression of herpes simplex virus type 2 US3 affects the Cdc42/Rac pathway and attenuates c-Jun N-terminal kinase activation.

Authors: T Murata; F Goshima; T Daikoku; H Takakuwa; Y Nishiyama
Journal: Genes Cells Date: 2000-12 Impact factor: 1.891

Subcellular localization of the alphaherpesvirus serine/threonine kinase Us3 as a determinant of Us3 function.

1. US3 protein kinase of herpes simplex virus protects primary afferent neurons from virus-induced apoptosis in ICR mice.

2. The US3 protein kinase of herpes simplex virus 1 mediates the posttranslational modification of BAD and prevents BAD-induced programmed cell death in the absence of other viral proteins.

3. Ultrastructural localization of the herpes simplex virus type 1 UL31, UL34, and US3 proteins suggests specific roles in primary envelopment and egress of nucleocapsids.

4. US3 protein kinase of herpes simplex virus type 2 plays a role in protecting corneal epithelial cells from apoptosis in infected mice.

5. Temporary disturbance of actin stress fibers in swine kidney cells during pseudorabies virus infection.

6. Antiapoptotic activity of herpes simplex virus type 2: the role of US3 protein kinase gene.

7. Effect of the deletion of US2 and US3 from herpes simplex virus type 2 on immune responses in the murine vagina following intravaginal infection.

8. Insertions in the gG gene of pseudorabies virus reduce expression of the upstream Us3 protein and inhibit cell-to-cell spread of virus infection.

9. Expression of herpes simplex virus type 2 US3 affects the Cdc42/Rac pathway and attenuates c-Jun N-terminal kinase activation.

10. Pseudorabies virus US3 protein kinase mediates actin stress fiber breakdown.

Review 1. Rho'ing in and out of cells: viral interactions with Rho GTPase signaling.

2. Nucleocytoplasmic shuttling of the HSV-2 serine/threonine kinase Us3.

Review 3. Actin' up: herpesvirus interactions with Rho GTPase signaling.

Review 4. Alphaherpesviruses and the cytoskeleton in neuronal infections.

Review 5. Cytoskeletons in the Closet-Subversion in Alphaherpesvirus Infections.