| Literature DB >> 10611736 |
S Hata1, A H Koyama, H Shiota, A Adachi, F Goshima, Y Nishiyama.
Abstract
In order to determine the ability of herpes simplex virus type 2 (HSV-2) to suppress apoptosis, we examined the effect of HSV-2 infection on apoptosis induced in HEp-2 cells by treatment with 1 M sorbitol. Although a wild-type strain of HSV-2 induced apoptosis in a significant fraction of the infected cells, HSV-2 could suppress sorbitol-induced apoptosis in a manner similar to that of herpes simplex virus type 1 (HSV-1), indicating that HSV-2, like HSV-1, has an antiapoptosis gene. Characterization of the cells infected with a US3-deletion mutant of HSV-2 revealed the necessity of a US3 gene in the antiapoptotic activity of this virus.Entities:
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Year: 1999 PMID： 10611736 DOI： 10.1016/s1286-4579(99)80059-8
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700