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Literature DB >> 12885923

Pseudorabies virus US3 protein kinase mediates actin stress fiber breakdown.

Geert Van Minnebruggen¹, Herman W Favoreel, Liesbeth Jacobs, Hans J Nauwynck.

Abstract

Disruption of specific components of the host cytoskeleton has been reported for several viruses and is thought to be beneficial for viral replication and spread. Our previous work demonstrated that infection of swine kidney (SK-6) cells with pseudorabies virus (PRV), a swine alphaherpesvirus, induced actin stress fiber breakdown. In the present study, using several PRV deletion mutants, we found that the US3 serine/threonine (S/T) protein kinase is involved in breakdown of actin stress fibers in different PRV-infected cell lines. Further, by transfection assays, we showed that PRV US3 itself, in the absence of other viral proteins, is able to trigger actin stress fiber breakdown when it is localized in sufficient amounts in the nucleus.

Entities: Chemical Gene Species

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Year: 2003 PMID： 12885923 PMCID： PMC167205 DOI： 10.1128/jvi.77.16.9074-9080.2003

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

37 in total

Review 1. Break ins and break outs: viral interactions with the cytoskeleton of Mammalian cells.

Authors: Gregory A Smith; Lynn W Enquist
Journal: Annu Rev Cell Dev Biol Date: 2002-04-02 Impact factor: 13.827

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Journal: J Virol Date: 1990-10 Impact factor: 5.103

3. Temporary disturbance of actin stress fibers in swine kidney cells during pseudorabies virus infection.

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Journal: Vet Microbiol Date: 2002-04-22 Impact factor: 3.293

4. Effect of the pseudorabies virus US3 protein on nuclear membrane localization of the UL34 protein and virus egress from the nucleus.

Authors: Barbara G Klupp; Harald Granzow; Thomas C Mettenleiter
Journal: J Gen Virol Date: 2001-10 Impact factor: 3.891

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Journal: J Gen Virol Date: 1990-08 Impact factor: 3.891

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Journal: J Gen Virol Date: 1990-08 Impact factor: 3.891

Review 7. vMIA, a viral inhibitor of apoptosis targeting mitochondria.

Authors: Victor S Goldmacher
Journal: Biochimie Date: 2002 Feb-Mar Impact factor: 4.079

8. Insertions in the gG gene of pseudorabies virus reduce expression of the upstream Us3 protein and inhibit cell-to-cell spread of virus infection.

Authors: G L Demmin; A C Clase; J A Randall; L W Enquist; B W Banfield
Journal: J Virol Date: 2001-11 Impact factor: 5.103

9. Fate of microfilaments in vero cells infected with measles virus and herpes simplex virus type 1.

Authors: E Bedows; K M Rao; M J Welsh
Journal: Mol Cell Biol Date: 1983-04 Impact factor: 4.272

10. Cell adhesion differentially regulates the nucleocytoplasmic distribution of active MAP kinases.

Authors: Andrew E Aplin; Brian P Hogan; Jeannie Tomeu; R L Juliano
Journal: J Cell Sci Date: 2002-07-01 Impact factor: 5.285

36 in total

Review 1. Viral serine/threonine protein kinases.

Authors: Thary Jacob; Céline Van den Broeke; Herman W Favoreel
Journal: J Virol Date: 2010-11-17 Impact factor: 5.103

2. The protein encoded by the US3 orthologue of Marek's disease virus is required for efficient de-envelopment of perinuclear virions and involved in actin stress fiber breakdown.

Authors: Daniel Schumacher; B Karsten Tischer; Sascha Trapp; Nikolaus Osterrieder
Journal: J Virol Date: 2005-04 Impact factor: 5.103

3. Cytoskeletal rearrangements and cell extensions induced by the US3 kinase of an alphaherpesvirus are associated with enhanced spread.

Authors: Herman W Favoreel; Geert Van Minnebruggen; Dirk Adriaensen; Hans J Nauwynck
Journal: Proc Natl Acad Sci U S A Date: 2005-06-10 Impact factor: 11.205

4. The pseudorabies virus VP1/2 tegument protein is required for intracellular capsid transport.

Authors: G W Gant Luxton; Joy I-Hsuan Lee; Sarah Haverlock-Moyns; Joseph Martin Schober; Gregory Allan Smith
Journal: J Virol Date: 2006-01 Impact factor: 5.103

5. Replication of herpes simplex virus: egress of progeny virus at specialized cell membrane sites.

Authors: Rebecca M Mingo; Jun Han; William W Newcomb; Jay C Brown
Journal: J Virol Date: 2012-04-24 Impact factor: 5.103

6. Phosphorylation of the varicella-zoster virus (VZV) major transcriptional regulatory protein IE62 by the VZV open reading frame 66 protein kinase.

Authors: Amie J Eisfeld; Stephanie E Turse; Sara A Jackson; Edwina C Lerner; Paul R Kinchington
Journal: J Virol Date: 2006-02 Impact factor: 5.103