BACKGROUND: Single-lung transplantation (SLT) and bilateral lung transplantation (BLT) are both good options for patients with end-stage lung disease secondary to idiopathic pulmonary fibrosis. It is, however, unclear whether BLT offers any survival advantage over SLT. The purpose of our study was to evaluate a large group of patients to determine if either SLT or BLT officered a long-term survival advantage for patients with IPF. METHODS: This was an Institutional Review Board-approved retrospective analysis of the United Network of Organ Sharing database from 1987 to 2008. Survival was determined using Kaplan-Meir estimates and the effect of laterality was determined by Cox proportional hazards and propensity analyses. RESULTS: Lung transplantation for idiopathic pulmonary fibrosis was performed in 3,860 patients (2,431 SLTs and 1429 BLTs). Multivariate and propensity analysis failed to show any survival advantage for BLT (hazard ratio = 0.90, 95% confidence interval = 0.78 to 1.0, p = 0.11). One-year conditional survival favored BLT (hazard ratio 0.73, 95% confidence interval 0.60 to 0.87, p = 0.00064). Risk factors for early death included recipient age over 57 and donor age over 36 years. CONCLUSIONS: Bilateral lung transplantation should be considered for younger patients with idiopathic pulmonary fibrosis and results may be optimized when younger donors are used.
BACKGROUND: Single-lung transplantation (SLT) and bilateral lung transplantation (BLT) are both good options for patients with end-stage lung disease secondary to idiopathic pulmonary fibrosis. It is, however, unclear whether BLT offers any survival advantage over SLT. The purpose of our study was to evaluate a large group of patients to determine if either SLT or BLT officered a long-term survival advantage for patients with IPF. METHODS: This was an Institutional Review Board-approved retrospective analysis of the United Network of Organ Sharing database from 1987 to 2008. Survival was determined using Kaplan-Meir estimates and the effect of laterality was determined by Cox proportional hazards and propensity analyses. RESULTS: Lung transplantation for idiopathic pulmonary fibrosis was performed in 3,860 patients (2,431 SLTs and 1429 BLTs). Multivariate and propensity analysis failed to show any survival advantage for BLT (hazard ratio = 0.90, 95% confidence interval = 0.78 to 1.0, p = 0.11). One-year conditional survival favored BLT (hazard ratio 0.73, 95% confidence interval 0.60 to 0.87, p = 0.00064). Risk factors for early death included recipient age over 57 and donor age over 36 years. CONCLUSIONS: Bilateral lung transplantation should be considered for younger patients with idiopathic pulmonary fibrosis and results may be optimized when younger donors are used.
Authors: Lois U Nwakanma; Christopher E Simpkins; Jason A Williams; David C Chang; Marvin C Borja; John V Conte; Ashish S Shah Journal: J Thorac Cardiovasc Surg Date: 2007-01-10 Impact factor: 5.209
Authors: David P Mason; Mariano E Brizzio; Joan M Alster; Ann M McNeill; Sudish C Murthy; Marie M Budev; Atul C Mehta; Omar A Minai; Gösta B Pettersson; Eugene H Blackstone Journal: Ann Thorac Surg Date: 2007-10 Impact factor: 4.330
Authors: Jason D Christie; Leah B Edwards; Paul Aurora; Fabienne Dobbels; Richard Kirk; Axel O Rahmel; Josef Stehlik; David O Taylor; Anna Y Kucheryavaya; Marshall I Hertz Journal: J Heart Lung Transplant Date: 2009-10 Impact factor: 10.247
Authors: T P M Whelan; J M Dunitz; R F Kelly; L B Edwards; C S Herrington; M I Hertz; P S Dahlberg Journal: J Heart Lung Transplant Date: 2005-09 Impact factor: 10.247
Authors: Claus Neurohr; Patrick Huppmann; Dolores Thum; Werner Leuschner; Werner von Wulffen; Tobias Meis; Hanno Leuchte; Rainer Baumgartner; Gregor Zimmermann; Rudolf Hatz; Stephan Czerner; Lorenz Frey; Peter Ueberfuhr; Iris Bittmann; Juergen Behr Journal: Transpl Int Date: 2010-03-05 Impact factor: 3.782
Authors: Dan M Meyer; Leah Bennett Edwards; Fernando Torres; Michael E Jessen; Richard J Novick Journal: Ann Thorac Surg Date: 2005-03 Impact factor: 4.330
Authors: M Rinaldi; F Sansone; M Boffini; S El Qarra; P Solidoro; N Cavallo; E Ruffini; S Baldi Journal: Transplant Proc Date: 2008 Jul-Aug Impact factor: 1.066
Authors: Gabriel Thabut; Jason D Christie; Philippe Ravaud; Yves Castier; Gaëlle Dauriat; Gilles Jebrak; Michel Fournier; Guy Lesèche; Raphaël Porcher; Hervé Mal Journal: Ann Intern Med Date: 2009-12-01 Impact factor: 25.391
Authors: Christine L Lau; David M Hoganson; Bryan F Meyers; Ralph J Damiano; G Alexander Patterson Journal: Ann Thorac Surg Date: 2006-04 Impact factor: 4.330
Authors: Jesse Cheng; Cody A Moore; Carlo J Iasella; Allan R Glanville; Matthew R Morrell; Randall B Smith; John F McDyer; Christopher R Ensor Journal: Clin Transplant Date: 2018-03-30 Impact factor: 2.863
Authors: M G Hartwig; A M Ganapathi; A A Osho; S A Hirji; B R Englum; P J Speicher; S M Palmer; R D Davis; L D Snyder Journal: Am J Transplant Date: 2016-07-15 Impact factor: 8.086
Authors: Brian C Gulack; Asvin M Ganapathi; Paul J Speicher; James M Meza; Sameer A Hirji; Laurie D Snyder; R Duane Davis; Matthew G Hartwig Journal: Ann Thorac Surg Date: 2015-07-23 Impact factor: 4.330
Authors: Liesbeth ten Klooster; George D Nossent; Johanna M Kwakkel-van Erp; Diana A van Kessel; Erik J Oudijk; Ed A van de Graaf; Bart Luijk; Rogier A Hoek; Bernt van den Blink; Peter Th van Hal; Erik A Verschuuren; Wim van der Bij; Coline H van Moorsel; Jan C Grutters Journal: Lung Date: 2015-09-24 Impact factor: 2.584
Authors: Domenico Calcaterra; Mohammad Bashir; John Keech; Michael J Bates; Joseph W Turek; Kalpaj R Parekh Journal: Ann Thorac Surg Date: 2014-10 Impact factor: 4.330