PURPOSE: Intensity modulated radiotherapy (IMRT) has been linked with an increased risk of secondary cancer induction due to the extra leakage radiation associated with delivery of these techniques. Removal of the flattening filter offers a simple way of reducing head leakage, and it may be possible to generate equivalent IMRT plans and to deliver these on a standard linear accelerator operating in unflattened mode. METHODS AND MATERIALS: An Elekta Precise linear accelerator has been commissioned to operate in both conventional and unflattened modes (energy matched at 6 MV) and a direct comparison made between the treatment planning and delivery of pediatric intracranial treatments using both approaches. These plans have been evaluated and delivered to an anthropomorphic phantom. RESULTS: Plans generated in unflattened mode are clinically identical to those for conventional IMRT but can be delivered with greatly reduced leakage radiation. Measurements in an anthropomorphic phantom at clinically relevant positions including the thyroid, lung, ovaries, and testes show an average reduction in peripheral doses of 23.7%, 29.9%, 64.9%, and 70.0%, respectively, for identical plan delivery compared to conventional IMRT. CONCLUSIONS: IMRT delivery in unflattened mode removes an unwanted and unnecessary source of scatter from the treatment head and lowers leakage doses by up to 70%, thereby reducing the risk of radiation-induced second cancers. Removal of the flattening filter is recommended for IMRT treatments.
PURPOSE: Intensity modulated radiotherapy (IMRT) has been linked with an increased risk of secondary cancer induction due to the extra leakage radiation associated with delivery of these techniques. Removal of the flattening filter offers a simple way of reducing head leakage, and it may be possible to generate equivalent IMRT plans and to deliver these on a standard linear accelerator operating in unflattened mode. METHODS AND MATERIALS: An Elekta Precise linear accelerator has been commissioned to operate in both conventional and unflattened modes (energy matched at 6 MV) and a direct comparison made between the treatment planning and delivery of pediatric intracranial treatments using both approaches. These plans have been evaluated and delivered to an anthropomorphic phantom. RESULTS: Plans generated in unflattened mode are clinically identical to those for conventional IMRT but can be delivered with greatly reduced leakage radiation. Measurements in an anthropomorphic phantom at clinically relevant positions including the thyroid, lung, ovaries, and testes show an average reduction in peripheral doses of 23.7%, 29.9%, 64.9%, and 70.0%, respectively, for identical plan delivery compared to conventional IMRT. CONCLUSIONS: IMRT delivery in unflattened mode removes an unwanted and unnecessary source of scatter from the treatment head and lowers leakage doses by up to 70%, thereby reducing the risk of radiation-induced second cancers. Removal of the flattening filter is recommended for IMRT treatments.
Authors: S Subramaniam; S Thirumalaiswamy; C Srinivas; G A Gandhi; M Kathirvel; K K Kumar; S Mallik; M Babaiah; Y Pawar; A Clivio; A Fogliata; P Mancosu; G Nicolini; E Vanetti; L Cozzi Journal: Strahlenther Onkol Date: 2012-03-10 Impact factor: 3.621
Authors: Brendan M Prendergast; Richard A Popple; Grant M Clark; Sharon A Spencer; Bart Guthrie; James Markert; John B Fiveash Journal: J Radiosurg SBRT Date: 2011
Authors: Geoffrey G Zhang; Lichung Ku; Thomas J Dilling; Craig W Stevens; Ray R Zhang; Weiqi Li; Vladimir Feygelman Journal: Radiat Oncol Date: 2011-11-09 Impact factor: 3.481
Authors: Brendan M Prendergast; Michael C Dobelbower; James A Bonner; Richard A Popple; Craig J Baden; Douglas J Minnich; Robert J Cerfolio; Sharon A Spencer; John B Fiveash Journal: Radiat Oncol Date: 2013-11-20 Impact factor: 3.481