Literature DB >> 21165464

Bis-phenanthroline copper(II) phthalate complexes are potent in vitro antitumour agents with 'self-activating' metallo-nuclease and DNA binding properties.

Andrew Kellett1, Mark O'Connor, Malachy McCann, Mary McNamara, Patrick Lynch, Georgina Rosair, Vickie McKee, Bernie Creaven, Maureen Walsh, Siobhan McClean, Agnieszka Foltyn, Denis O'Shea, Orla Howe, Michael Devereux.   

Abstract

Three, structurally characterised, bis-phen Cu(II) complexes of the phthalate isomers display rapid, low micromolar in vitro cytotoxicity against a range of epithelial tumour cells. The complexes induce relaxation of supercoiled plasmid DNA in the absence of external reducing agents and display efficient CT-DNA, Poly[d(A-T)](2) and Poly[d(G-C)](2) binding.

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Year:  2010        PMID： 21165464     DOI： 10.1039/c0dt01607a

Source DB:  PubMed          Journal:  Dalton Trans        ISSN： 1477-9226            Impact factor:   4.390


  11 in total

1.  Nuclease activity via self-activation and anticancer activity of a mononuclear copper(II) complex: novel role of the tertiary butyl group in the ligand frame.

Authors:  Kaushik Ghosh; Pramod Kumar; Varun Mohan; Udai P Singh; Sahba Kasiri; Subhrangsu S Mandal
Journal:  Inorg Chem       Date:  2012-02-28       Impact factor: 5.165

2.  Antifungal Potential of Copper(II), Manganese(II) and Silver(I) 1,10-Phenanthroline Chelates Against Multidrug-Resistant Fungal Species Forming the Candida haemulonii Complex: Impact on the Planktonic and Biofilm Lifestyles.

Authors:  Rafael M Gandra; Pauraic Mc Carron; Mariana F Fernandes; Lívia S Ramos; Thaís P Mello; Ana Carolina Aor; Marta H Branquinha; Malachy McCann; Michael Devereux; André L S Santos
Journal:  Front Microbiol       Date:  2017-07-11       Impact factor: 5.640

3.  Triggering autophagic cell death with a di-manganese(II) developmental therapeutic.

Authors:  Creina Slator; Zara Molphy; Vickie McKee; Andrew Kellett
Journal:  Redox Biol       Date:  2017-02-04       Impact factor: 11.799

4.  (E)-6,6'-(Diazene-1,2-di-yl)bis-(1,10-phenanthrolin-5-ol) tri-chloro-methane disolvate: a superconjugated ligand.

Authors:  Muhib Ahmed; Michael Devereux; Vickie McKee; Malachy McCann; A Denise Rooney
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-07-23

5.  Copper bis-Dipyridoquinoxaline Is a Potent DNA Intercalator that Induces Superoxide-Mediated Cleavage via the Minor Groove.

Authors:  Zara Molphy; Vickie McKee; Andrew Kellett
Journal:  Molecules       Date:  2019-11-26       Impact factor: 4.411

Review 6.  Copper(II) Phenanthroline-Based Complexes as Potential AntiCancer Drugs: A Walkthrough on the Mechanisms of Action.

Authors:  Sebastiano Masuri; Petr Vaňhara; Maria Grazia Cabiddu; Lukáš Moráň; Josef Havel; Enzo Cadoni; Tiziana Pivetta
Journal:  Molecules       Date:  2021-12-22       Impact factor: 4.411

7.  DNA oxidation profiles of copper phenanthrene chemical nucleases.

Authors:  Zara Molphy; Creina Slator; Chryssostomos Chatgilialoglu; Andrew Kellett
Journal:  Front Chem       Date:  2015-04-21       Impact factor: 5.221

8.  Interaction of Iron II Complexes with B-DNA. Insights from Molecular Modeling, Spectroscopy, and Cellular Biology.

Authors:  Hugo Gattuso; Thibaut Duchanois; Vanessa Besancenot; Claire Barbieux; Xavier Assfeld; Philippe Becuwe; Philippe C Gros; Stephanie Grandemange; Antonio Monari
Journal:  Front Chem       Date:  2015-12-18       Impact factor: 5.221

9.  Di-copper metallodrugs promote NCI-60 chemotherapy via singlet oxygen and superoxide production with tandem TA/TA and AT/AT oligonucleotide discrimination.

Authors:  Creina Slator; Zara Molphy; Vickie McKee; Conor Long; Tom Brown; Andrew Kellett
Journal:  Nucleic Acids Res       Date:  2018-04-06       Impact factor: 16.971

10.  [Ag(L)NO3] Complexes with 2-Benzoylpyridine-Derived Hydrazones: Cytotoxic Activity and Interaction with Biomolecules.

Authors:  Ane F Santos; Isabella P Ferreira; Carlos B Pinheiro; Verlane G Santos; Miriam T P Lopes; Letícia R Teixeira; Willian R Rocha; Gabriel L S Rodrigues; Heloisa Beraldo
Journal:  ACS Omega       Date:  2018-06-28
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