Shelli R Kesler1, Norman J Lacayo, Booil Jo. 1. Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA. skesler@stanford.edu
Abstract
PRIMARY OBJECTIVES:Children with a history of cancer are at increased risk for cognitive impairments, particularly in executive and memory domains. Traditional, in-person cognitive rehabilitation strategies may be unavailable and/or impractical for many of these children given difficulties related to resources and health status. The feasibility and efficacy of implementing a computerized, home-based cognitive rehabilitation curriculum designed to improve executive function skills was examined in these children. METHODS: A one-arm open trial pilot study of an original executive function cognitive rehabilitation curriculum was conducted with 23 paediatric cancer survivors aged 7-19. RESULTS: Compliance with the cognitive rehabilitation program was 83%, similar to that of many traditional programs. Following the cognitive intervention, participants showed significantly increased processing speed, cognitive flexibility, verbal and visual declarative memory scores as well as significantly increased pre-frontal cortex activation compared to baseline. CONCLUSIONS: These results suggest that a program of computerized cognitive exercises can be successfully implemented at home in young children with cancer. These exercises may be effective for improving executive and memory skills in this group, with concurrent changes in neurobiologic status.
RCT Entities:
PRIMARY OBJECTIVES:Children with a history of cancer are at increased risk for cognitive impairments, particularly in executive and memory domains. Traditional, in-person cognitive rehabilitation strategies may be unavailable and/or impractical for many of these children given difficulties related to resources and health status. The feasibility and efficacy of implementing a computerized, home-based cognitive rehabilitation curriculum designed to improve executive function skills was examined in these children. METHODS: A one-arm open trial pilot study of an original executive function cognitive rehabilitation curriculum was conducted with 23 paediatric cancer survivors aged 7-19. RESULTS: Compliance with the cognitive rehabilitation program was 83%, similar to that of many traditional programs. Following the cognitive intervention, participants showed significantly increased processing speed, cognitive flexibility, verbal and visual declarative memory scores as well as significantly increased pre-frontal cortex activation compared to baseline. CONCLUSIONS: These results suggest that a program of computerized cognitive exercises can be successfully implemented at home in young children with cancer. These exercises may be effective for improving executive and memory skills in this group, with concurrent changes in neurobiologic status.
Authors: Eija Pääkkö; Satu Lehtinen; Arja Harila-Saari; Aapo Ahonen; Jukka Jauhiainen; Pentti Torniainen; Juhani Pyhtinen; Marjatta Lanning Journal: Med Pediatr Oncol Date: 2003-02
Authors: Shawna L Palmer; Amar Gajjar; Wilburn E Reddick; John O Glass; Larry E Kun; Shengjie Wu; Xiaoping Xiong; Raymond K Mulhern Journal: Neuropsychology Date: 2003-10 Impact factor: 3.295
Authors: Pek-Lan Khong; Dora L W Kwong; Godfrey C F Chan; Jonathan S T Sham; Fu-Luk Chan; Gaik-Cheng Ooi Journal: AJNR Am J Neuroradiol Date: 2003-04 Impact factor: 3.825
Authors: Lauren E Cox; Jason M Ashford; Kellie N Clark; Karen Martin-Elbahesh; Kristina K Hardy; Thomas E Merchant; Robert J Ogg; Sima Jeha; Victoria W Willard; Lu Huang; Hui Zhang; Heather M Conklin Journal: Neurooncol Pract Date: 2015-03-13
Authors: S M Hadi Hosseini; Mika Pritchard-Berman; Natasha Sosa; Angelica Ceja; Shelli R Kesler Journal: Neuroimage Date: 2016-03-22 Impact factor: 6.556
Authors: Heather M Conklin; Robert J Ogg; Jason M Ashford; Matthew A Scoggins; Ping Zou; Kellie N Clark; Karen Martin-Elbahesh; Kristina K Hardy; Thomas E Merchant; Sima Jeha; Lu Huang; Hui Zhang Journal: J Clin Oncol Date: 2015-10-12 Impact factor: 44.544
Authors: Ashley S Fournier-Goodnight; Jason M Ashford; Kellie N Clark; Karen Martin-Elbahesh; Kristina K Hardy; Thomas E Merchant; Sima Jeha; Robert J Ogg; Hui Zhang; Lei Wang; Heather M Conklin Journal: Appl Neuropsychol Child Date: 2017-11-21 Impact factor: 1.493
Authors: Sunita K Patel; Leticia Miranda; Nicole Delgado; Nicolas Barreto; Anne Nolty; Natalie C Kelly; Karla Wilson; Debbie Toomey; Anna Pawlowska Journal: J Pediatr Psychol Date: 2020-09-01
Authors: Tara M Brinkman; Wilburn E Reddick; Joshua Luxton; John O Glass; Noah D Sabin; Deo Kumar Srivastava; Leslie L Robison; Melissa M Hudson; Kevin R Krull Journal: Neuro Oncol Date: 2012-09 Impact factor: 12.300
Authors: Sunita K Patel; Paula Ross; Michelle Cuevas; Anne Turk; Heeyoung Kim; Tracy T Y Lo; Lennie F Wong; Smita Bhatia Journal: J Pediatr Psychol Date: 2014-06-25