Literature DB >> 21136202

AID expression during B-cell development: searching for answers.

Masayuki Kuraoka1, Laurie McWilliams, Garnett Kelsoe.   

Abstract

Expression of activation-induced cytidine deaminase (AID) by germinal center (GC) B cells drives the processes of immunoglobulin (Ig) somatic hypermutation (SHM) and class switch recombination (CSR) necessary for the generation of high affinity IgG serum antibody and the memory B-cell compartment. Increasing evidence indicates that AID is also expressed at low levels in developing B cells but to date, this early, developmentally regulated AID expression has no known function. Does the timing and extent of AID expression in developmentally immature, non-GC B cells provide clues to reveal its physiologic role?

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Year:  2011        PMID： 21136202     DOI： 10.1007/s12026-010-8185-7

Source DB:  PubMed          Journal:  Immunol Res        ISSN： 0257-277X            Impact factor:   2.829


  78 in total

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  7 in total

Review 1.  Complex regulation and function of activation-induced cytidine deaminase.

Authors:  Janet Stavnezer
Journal:  Trends Immunol       Date:  2011-04-13       Impact factor: 16.687

2.  Both CpG methylation and activation-induced deaminase are required for the fragility of the human bcl-2 major breakpoint region: implications for the timing of the breaks in the t(14;18) translocation.

Authors:  Xiaoping Cui; Zhengfei Lu; Aya Kurosawa; Lars Klemm; Andrew T Bagshaw; Albert G Tsai; Neil Gemmell; Markus Müschen; Noritaka Adachi; Chih-Lin Hsieh; Michael R Lieber
Journal:  Mol Cell Biol       Date:  2012-12-21       Impact factor: 4.272

3.  An Unmutated IgM Response to the Vi Polysaccharide of Salmonella Typhi Contributes to Protective Immunity in a Murine Model of Typhoid.

Authors:  Kalgi D Pandya; Isabel Palomo-Caturla; Justin A Walker; Vijay K Sandilya; Zhijiu Zhong; Kishore R Alugupalli
Journal:  J Immunol       Date:  2018-05-09       Impact factor: 5.422

4.  Overexpression of Activation-Induced Cytidine Deaminase in MTX- and Age-Related Epstein-Barr Virus-Associated B-Cell Lymphoproliferative Disorders of the Head and Neck.

Authors:  Kentaro Kikuchi; Toshiyuki Ishige; Fumio Ide; Yumi Ito; Ichiro Saito; Miyako Hoshino; Harumi Inoue; Yuji Miyazaki; Tadashige Nozaki; Masaru Kojima; Kaoru Kusama
Journal:  J Oncol       Date:  2015-03-05       Impact factor: 4.375

5.  Targeting antigens to CD180 rapidly induces antigen-specific IgG, affinity maturation, and immunological memory.

Authors:  Jay W Chaplin; Craig P Chappell; Edward A Clark
Journal:  J Exp Med       Date:  2013-09-09       Impact factor: 14.307

6.  CD25 + B-1a Cells Express Aicda.

Authors:  Hiroaki Kaku; Nichol E Holodick; Joseph R Tumang; Thomas L Rothstein
Journal:  Front Immunol       Date:  2017-06-20       Impact factor: 7.561

Review 7.  Epstein-Barr virus (EBV)-associated epithelial and non-epithelial lesions of the oral cavity.

Authors:  Kentaro Kikuchi; Harumi Inoue; Yuji Miyazaki; Fumio Ide; Masaru Kojima; Kaoru Kusama
Journal:  Jpn Dent Sci Rev       Date:  2017-03-15
  7 in total

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