BACKGROUND: Predictive disease risk biomarkers that can be linked to exposure have proved difficult to identify in case-control studies. METHODS: Parallel statistical analysis of the correlation between (1)H NMR profiles from plasma samples collected before disease onset (EPIC cohort), versus exposure to dietary compounds, and follow-up disease endpoints (colon and breast cancer) was performed. RESULTS: Metabonomic signatures associated with colon cancer and dietary fiber intake (a protective factor according to epidemiological studies) were identified. CONCLUSION: This implementation of the novel "meet-in-the-middle" analytical strategy indicates how case-control studies nested in prospectively collected cohorts may reveal intermediate biomarkers linking exposure and disease.
BACKGROUND: Predictive disease risk biomarkers that can be linked to exposure have proved difficult to identify in case-control studies. METHODS: Parallel statistical analysis of the correlation between (1)H NMR profiles from plasma samples collected before disease onset (EPIC cohort), versus exposure to dietary compounds, and follow-up disease endpoints (colon and breast cancer) was performed. RESULTS: Metabonomic signatures associated with colon cancer and dietary fiber intake (a protective factor according to epidemiological studies) were identified. CONCLUSION: This implementation of the novel "meet-in-the-middle" analytical strategy indicates how case-control studies nested in prospectively collected cohorts may reveal intermediate biomarkers linking exposure and disease.
Authors: Caroline L Ring; Jon A Arnot; Deborah H Bennett; Peter P Egeghy; Peter Fantke; Lei Huang; Kristin K Isaacs; Olivier Jolliet; Katherine A Phillips; Paul S Price; Hyeong-Moo Shin; John N Westgate; R Woodrow Setzer; John F Wambaugh Journal: Environ Sci Technol Date: 2018-12-24 Impact factor: 9.028
Authors: Alice Ly; Achim Buck; Benjamin Balluff; Na Sun; Karin Gorzolka; Annette Feuchtinger; Klaus-Peter Janssen; Peter J K Kuppen; Cornelis J H van de Velde; Gregor Weirich; Franziska Erlmeier; Rupert Langer; Michaela Aubele; Horst Zitzelsberger; Liam McDonnell; Michaela Aichler; Axel Walch Journal: Nat Protoc Date: 2016-07-14 Impact factor: 13.491
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