Emma E McGee1,2, Rama Kiblawi3, Mary C Playdon3,4, A Heather Eliassen5,6. 1. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. emcgee@hsph.harvard.edu. 2. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. emcgee@hsph.harvard.edu. 3. Division of Cancer Population Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. 4. Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA. 5. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 6. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Abstract
PURPOSE OF REVIEW: Metabolomics offers several opportunities for advancement in nutritional cancer epidemiology; however, numerous research gaps and challenges remain. This narrative review summarizes current research, challenges, and future directions for epidemiologic studies of nutritional metabolomics and cancer. RECENT FINDINGS: Although many studies have used metabolomics to investigate either dietary exposures or cancer, few studies have explicitly investigated diet-cancer relationships using metabolomics. Most studies have been relatively small (≤ ~ 250 cases) or have assessed a limited number of nutritional metabolites (e.g., coffee or alcohol-related metabolites). Nutritional metabolomic investigations of cancer face several challenges in study design; biospecimen selection, handling, and processing; diet and metabolite measurement; statistical analyses; and data sharing and synthesis. More metabolomics studies linking dietary exposures to cancer risk, prognosis, and survival are needed, as are biomarker validation studies, longitudinal analyses, and methodological studies. Despite the remaining challenges, metabolomics offers a promising avenue for future dietary cancer research.
PURPOSE OF REVIEW: Metabolomics offers several opportunities for advancement in nutritional cancer epidemiology; however, numerous research gaps and challenges remain. This narrative review summarizes current research, challenges, and future directions for epidemiologic studies of nutritional metabolomics and cancer. RECENT FINDINGS: Although many studies have used metabolomics to investigate either dietary exposures or cancer, few studies have explicitly investigated diet-cancer relationships using metabolomics. Most studies have been relatively small (≤ ~ 250 cases) or have assessed a limited number of nutritional metabolites (e.g., coffee or alcohol-related metabolites). Nutritional metabolomic investigations of cancer face several challenges in study design; biospecimen selection, handling, and processing; diet and metabolite measurement; statistical analyses; and data sharing and synthesis. More metabolomics studies linking dietary exposures to cancer risk, prognosis, and survival are needed, as are biomarker validation studies, longitudinal analyses, and methodological studies. Despite the remaining challenges, metabolomics offers a promising avenue for future dietary cancer research.
Authors: Shilpa N Bhupathiraju; Marta Guasch-Ferré; Meghana D Gadgil; Christopher B Newgard; James R Bain; Michael J Muehlbauer; Olga R Ilkayeva; Denise M Scholtens; Frank B Hu; Alka M Kanaya; Namratha R Kandula Journal: J Nutr Date: 2018-07-01 Impact factor: 4.798
Authors: Giuseppe Paglia; Fabiola M Del Greco; Baldur B Sigurdsson; Johannes Rainer; Chiara Volani; Andrew A Hicks; Peter P Pramstaller; Sigurdur V Smarason Journal: Clin Chim Acta Date: 2018-08-13 Impact factor: 3.786
Authors: Päivi P Söderholm; Anja H Koskela; Johan E Lundin; Matti J Tikkanen; Herman C Adlercreutz Journal: Am J Clin Nutr Date: 2009-09-16 Impact factor: 7.045
Authors: Mary K Townsend; Ying Bao; Clary B Clish; Shelley S Tworoger; Elizabeth M Poole; Kimberly A Bertrand; Peter Kraft; Brian M Wolpin Journal: Cancer Epidemiol Biomarkers Prev Date: 2016-03-03 Impact factor: 4.254
Authors: Timothy Jewison; Craig Knox; Vanessa Neveu; Yannick Djoumbou; An Chi Guo; Jacqueline Lee; Philip Liu; Rupasri Mandal; Ram Krishnamurthy; Igor Sinelnikov; Michael Wilson; David S Wishart Journal: Nucleic Acids Res Date: 2011-11-07 Impact factor: 16.971
Authors: L O Dragsted; Q Gao; A Scalbert; G Vergères; M Kolehmainen; C Manach; L Brennan; L A Afman; D S Wishart; C Andres Lacueva; M Garcia-Aloy; H Verhagen; E J M Feskens; G Praticò Journal: Genes Nutr Date: 2018-05-30 Impact factor: 5.523
Authors: Sylvia L Crowder; Mary C Playdon; Lisa M Gudenkauf; Jennifer Ose; Biljana Gigic; Leigh Greathouse; Anita R Peoples; Alix G Sleight; Heather S L Jim; Jane C Figueiredo Journal: Nutrients Date: 2022-04-02 Impact factor: 6.706