Literature DB >> 21112675

Synthesis and in vitro anticancer evaluation of some novel hexahydroquinoline derivatives having a benzenesulfonamide moiety.

Mansour S Al-Said1, Mostafa M Ghorab, Mohammed S Al-Dosari, Mostafa M Hamed.   

Abstract

Inhibition of carbonic anhydrase isozymes has been found to have a role in the treatment of cancer. Several sulfonamide compounds bearing an aromatic or a heteroaromatic ring were found to posses potent carbonic anhydrase inhibitory activity and so can be used in the treatment of several types of cancer. In this paper, we present the synthesis of some novel quinoline 7-13, 21-26, 28 and pyrimidoquinoline 14-18, 20, 27 derivatives having a sulfonamide moiety. All the newly synthesized compounds were evaluated for their in vitro anticancer activity. Several compounds showed interesting cytotoxic activities when compared with the used reference drug. In addition, docking of the synthesized compounds into carbonic anhydrase isozyme II (CA II) active site was performed in order to give a suggestion about the proposed mechanism of action.
Copyright © 2010 Elsevier Masson SAS. All rights reserved.

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Year:  2010        PMID： 21112675     DOI： 10.1016/j.ejmech.2010.11.002

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  7 in total

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Authors:  K Shakuntala; S Naveen; N K Lokanath; P A Suchetan
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-04-11

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Authors:  D R Naveen Kumar; V Cijo George; P K Suresh; R Ashok Kumar
Journal:  EXCLI J       Date:  2013-06-04       Impact factor: 4.068

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Authors:  Muhammad Athar Abbasi; Amna Saeed; Khalid Mohmmed Khan; Muhammad Ashraf; Syeda Abida Ejaz
Journal:  Iran J Pharm Res       Date:  2014       Impact factor: 1.696

6.  Crystal structures of 4-meth-oxy-N-(4-methyl-phenyl)benzene-sulfonamide and N-(4-fluoro-phenyl)-4-meth-oxy-benzene-sulfonamide.

Authors:  Vinola Z Rodrigues; C P Preema; S Naveen; N K Lokanath; P A Suchetan
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-10-28

7.  Design, synthesis, and biological evaluation of novel N 4 -substituted sulfonamides: acetamides derivatives as dihydrofolate reductase (DHFR) inhibitors.

Authors:  Essam M Hussein; Munirah M Al-Rooqi; Shimaa M Abd El-Galil; Saleh A Ahmed
Journal:  BMC Chem       Date:  2019-07-11
  7 in total

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