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Literature DB >> 21107750

The value of epigenetic markers in esophageal cancer.

Abstract

Developing esophageal cancer is a multi-step process that begins with the accumulation of genetic and epigenetic alterations, and leads to the activation of oncogenes and the inactivation or loss of tumor suppressor genes (TSG). In addition to genetic alteration, epigenetic modifications, and in particular DNA methylation, are recognized as a common molecular alteration in human tumors. In esophageal cancer, aberrant methylation of promoter regions occurs not only in advanced cancer, but also in premalignant lesions. DNA methylation is related to survival time and sensitivity of chemoradiotherapy. This review is mainly focused on epigenetic changes in esophageal cancer and the value of early detection for patient prognosis, treatment choices, and potential targeting therapy.

Entities: Disease Species

Mesh：

Substances：
Genetic Markers

Year: 2010 PMID： 21107750 DOI： 10.1007/s11684-010-0230-3

Source DB: PubMed Journal: Front Med China ISSN： 1673-7342

64 in total

Review 1. X-chromosome inactivation and cell memory.

Authors: A D Riggs; G P Pfeifer
Journal: Trends Genet Date: 1992-05 Impact factor: 11.639

Review 2. Neoadjuvant treatment of esophageal cancer.

Authors: Nicholas P Campbell; Victoria M Villaflor
Journal: World J Gastroenterol Date: 2010-08-14 Impact factor: 5.742

3. p16INK4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas.

Authors: D J Wong; M T Barrett; R Stöger; M J Emond; B J Reid
Journal: Cancer Res Date: 1997-07-01 Impact factor: 12.701

4. CpG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme.

Authors: Ramon Martinez; Fernando Setien; Christiane Voelter; Sara Casado; Maria P Quesada; Gabriele Schackert; Manel Esteller
Journal: Carcinogenesis Date: 2007-02-01 Impact factor: 4.944

5. Cancer-specific methylation in the BRCA1 promoter in sporadic breast tumours.

Authors: Azhar B Ali; Philip T C Iau; Jen-Hwei Sng
Journal: Med Oncol Date: 2010-02-05 Impact factor: 3.064

Review 6. Epidemiological aspects of oesophageal cancer.

Authors: N Muñoz
Journal: Endoscopy Date: 1993-11 Impact factor: 10.093

7. Loss of disabled-2 expression is an early event in esophageal squamous tumorigenesis.

Authors: Kumar Anupam; Chatopadhyay Tusharkant; Siddhartha Datta Gupta; Ralhan Ranju
Journal: World J Gastroenterol Date: 2006-10-07 Impact factor: 5.742

8. Promoter methylation of HIN-1 in the progression to esophageal squamous cancer.

Authors: Mingzhou Guo; Jingli Ren; Malcolm V Brock; James G Herman; Hetty E Carraway
Journal: Epigenetics Date: 2008-11-08 Impact factor: 4.528

9. Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer.

Authors: O Aguilera; M F Fraga; E Ballestar; M F Paz; M Herranz; J Espada; J M García; A Muñoz; M Esteller; J M González-Sancho
Journal: Oncogene Date: 2006-02-20 Impact factor: 9.867

10. Expression of esophageal cancer related gene 4 (ECRG4), a novel tumor suppressor gene, in esophageal cancer and its inhibitory effect on the tumor growth in vitro and in vivo.

Authors: Lin-Wei Li; Xi-Ying Yu; Yang Yang; Chun-Peng Zhang; Li-Ping Guo; Shih-Hsin Lu
Journal: Int J Cancer Date: 2009-10-01 Impact factor: 7.396

18 in total

1. p16 hypermethylation: a biomarker for increased esophageal cancer susceptibility in high incidence region of North East India.

Authors: Mandakini Das; Bhaskar Jyoti Saikia; Santanu Kumar Sharma; Gaganpreet Singh Sekhon; Jagadish Mahanta; Rup Kumar Phukan
Journal: Tumour Biol Date: 2014-11-01

The value of epigenetic markers in esophageal cancer.

Review 1. X-chromosome inactivation and cell memory.

Review 2. Neoadjuvant treatment of esophageal cancer.

3. p16INK4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas.

4. CpG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme.

5. Cancer-specific methylation in the BRCA1 promoter in sporadic breast tumours.

Review 6. Epidemiological aspects of oesophageal cancer.

7. Loss of disabled-2 expression is an early event in esophageal squamous tumorigenesis.

8. Promoter methylation of HIN-1 in the progression to esophageal squamous cancer.

9. Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer.

10. Expression of esophageal cancer related gene 4 (ECRG4), a novel tumor suppressor gene, in esophageal cancer and its inhibitory effect on the tumor growth in vitro and in vivo.

1. p16 hypermethylation: a biomarker for increased esophageal cancer susceptibility in high incidence region of North East India.

Review 2. Epigenetic biomarkers in esophageal cancer.

3. DNA methylation biomarkers for head and neck squamous cell carcinoma.

4. Methylation of TFPI-2 is an early event of esophageal carcinogenesis.

Review 5. Epigenetic alterations and their clinical implications in esophageal squamous cell carcinoma.

6. Aloe-emodin suppresses esophageal cancer cell TE1 proliferation by inhibiting AKT and ERK phosphorylation.

7. Epigenetics in the Pathogenesis of Esophageal Adenocarcinoma.

Review 8. Genetic and Epigenetic Alterations in Barrett's Esophagus and Esophageal Adenocarcinoma.

9. Epigenetic regulation of the Wnt signaling inhibitor DACT2 in human hepatocellular carcinoma.

10. Endoglin promoter hypermethylation identifies a field defect in human primary esophageal cancer.