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Literature DB >> 26021206

Genetic and Epigenetic Alterations in Barrett's Esophagus and Esophageal Adenocarcinoma.

Andrew M Kaz¹, William M Grady², Matthew D Stachler³, Adam J Bass⁴.

Abstract

Esophageal adenocarcinoma (EAC) develops from Barrett's esophagus (BE), wherein normal squamous epithelia is replaced by specialized intestinal metaplasia in response to chronic gastroesophageal acid reflux. BE can progress to low- and high-grade dysplasia, intramucosal, and invasive carcinoma. Both BE and EAC are characterized by loss of heterozygosity, aneuploidy, specific genetic mutations, and clonal diversity. Given the limitations of histopathology, genomic and epigenomic analyses may improve the precision of risk stratification. Assays to detect molecular alterations associated with neoplastic progression could be used to improve the pathologic assessment of BE/EAC and to select high-risk patients for more intensive surveillance.

Entities: Chemical Disease Gene Species

Keywords: Aneuploidy; Barrett’s esophagus; Cancer genomics; DNA methylation; Esophageal adenocarcinoma; Genomic instability; LOH

Mesh：

Substances：
MicroRNAs

Year: 2015 PMID： 26021206 PMCID： PMC4449457 DOI： 10.1016/j.gtc.2015.02.015

Source DB: PubMed Journal: Gastroenterol Clin North Am ISSN： 0889-8553 Impact factor: 3.806

89 in total

Review 1. Epidemiologic trends in esophageal and gastric cancer in the United States.

Authors: Linda Morris Brown; Susan S Devesa
Journal: Surg Oncol Clin N Am Date: 2002-04 Impact factor: 3.495

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Journal: Cancer Res Date: 1997-07-01 Impact factor: 12.701

3. Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma.

Authors: Nishant Agrawal; Yuchen Jiao; Chetan Bettegowda; Susan M Hutfless; Yuxuan Wang; Stefan David; Yulan Cheng; William S Twaddell; Nyan L Latt; Eun J Shin; Li-Dong Wang; Liang Wang; Wancai Yang; Victor E Velculescu; Bert Vogelstein; Nickolas Papadopoulos; Kenneth W Kinzler; Stephen J Meltzer
Journal: Cancer Discov Date: 2012-08-09 Impact factor: 39.397

4. Methylation of SOCS-3 and SOCS-1 in the carcinogenesis of Barrett's adenocarcinoma.

Authors: I Tischoff; U R Hengge; M Vieth; C Ell; M Stolte; A Weber; W E Schmidt; A Tannapfel
Journal: Gut Date: 2007-03-21 Impact factor: 23.059

5. Frequent hypermethylation of the 5' CpG island of E-cadherin in esophageal adenocarcinoma.

Authors: P G Corn; E I Heath; R Heitmiller; F Fogt; A A Forastiere; J G Herman; T T Wu
Journal: Clin Cancer Res Date: 2001-09 Impact factor: 12.531

6. Genome-scale analysis of aberrant DNA methylation in colorectal cancer.

Authors: Toshinori Hinoue; Daniel J Weisenberger; Christopher P E Lange; Hui Shen; Hyang-Min Byun; David Van Den Berg; Simeen Malik; Fei Pan; Houtan Noushmehr; Cornelis M van Dijk; Rob A E M Tollenaar; Peter W Laird
Journal: Genome Res Date: 2011-06-09 Impact factor: 9.043

Review 7. DNA methylation and cancer pathways in gastrointestinal tumors.

Authors: Hiromu Suzuki; Takashi Tokino; Yasuhisa Shinomura; Kohzoh Imai; Minoru Toyota
Journal: Pharmacogenomics Date: 2008-12 Impact factor: 2.533

8. DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma.

Authors: D F Peng; M Razvi; H Chen; K Washington; A Roessner; R Schneider-Stock; W El-Rifai
Journal: Gut Date: 2008-07-29 Impact factor: 23.059

9. Determination of the frequency of loss of heterozygosity in esophageal adenocarcinoma by cell sorting, whole genome amplification and microsatellite polymorphisms.

Authors: M T Barrett; P C Galipeau; C A Sanchez; M J Emond; B J Reid
Journal: Oncogene Date: 1996-05-02 Impact factor: 9.867

10. E-cadherin expression in primary and metastatic thoracic neoplasms and in Barrett's oesophagus.

Authors: P F Bongiorno; M al-Kasspooles; S W Lee; W J Rachwal; J H Moore; R I Whyte; M B Orringer; D G Beer
Journal: Br J Cancer Date: 1995-01 Impact factor: 7.640

19 in total

1. CDX-2 Expression in Esophageal Biopsies Without Goblet Cell Intestinal Metaplasia May Be Predictive of Barrett's Esophagus.

Authors: James Saller; Sameer Al Diffalha; Kevin Neill; Rahill A Bhaskar; Cecilia Oliveri; David Boulware; Henry Levine; Isaac Kalvaria; F Scott Corbett; Arun Khazanchi; Jason Klapman; Domenico Coppola
Journal: Dig Dis Sci Date: 2019-11-05 Impact factor: 3.199

Review 2. Evolution of Premalignant Disease.

Authors: Kit Curtius; Nicholas A Wright; Trevor A Graham
Journal: Cold Spring Harb Perspect Med Date: 2017-12-01 Impact factor: 6.915

3. Locoregional Tumor Extension and Preoperative Smoking are Significant Risk Factors for Early Recurrence After Esophagectomy for Cancer.

Authors: Styliani Mantziari; Pierre Allemann; Michael Winiker; Nicolas Demartines; Markus Schäfer
Journal: World J Surg Date: 2018-07 Impact factor: 3.352

Genetic and Epigenetic Alterations in Barrett's Esophagus and Esophageal Adenocarcinoma.

Review 1. Epidemiologic trends in esophageal and gastric cancer in the United States.

2. p16INK4a promoter is hypermethylated at a high frequency in esophageal adenocarcinomas.

3. Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma.

4. Methylation of SOCS-3 and SOCS-1 in the carcinogenesis of Barrett's adenocarcinoma.

5. Frequent hypermethylation of the 5' CpG island of E-cadherin in esophageal adenocarcinoma.

6. Genome-scale analysis of aberrant DNA methylation in colorectal cancer.

Review 7. DNA methylation and cancer pathways in gastrointestinal tumors.

8. DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma.

9. Determination of the frequency of loss of heterozygosity in esophageal adenocarcinoma by cell sorting, whole genome amplification and microsatellite polymorphisms.

10. E-cadherin expression in primary and metastatic thoracic neoplasms and in Barrett's oesophagus.

1. CDX-2 Expression in Esophageal Biopsies Without Goblet Cell Intestinal Metaplasia May Be Predictive of Barrett's Esophagus.

Review 2. Evolution of Premalignant Disease.

3. Locoregional Tumor Extension and Preoperative Smoking are Significant Risk Factors for Early Recurrence After Esophagectomy for Cancer.

Review 4. Today's Mistakes and Tomorrow's Wisdom in Development and Use of Biomarkers for Barrett's Esophagus.

Review 5. An evolutionary perspective on field cancerization.

Review 6. Metaplasia: tissue injury adaptation and a precursor to the dysplasia-cancer sequence.

Review 7. Endoscopic or Surgical Resection for Gastro-Esophageal Cancer.

Review 8. Molecular Evolution of Metaplasia to Adenocarcinoma in the Esophagus.

Review 9. Oesophageal adenocarcinoma and gastric cancer: should we mind the gap?

Review 10. Epigenetic Alterations in the Gastrointestinal Tract: Current and Emerging Use for Biomarkers of Cancer.