Literature DB >> 21105032

Engineering peptide inhibitors to overcome PDZ binding promiscuity.

Lars Vouilleme1, Patrick R Cushing, Rudolf Volkmer, Dean R Madden, Prisca Boisguerin.   

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Year:  2010        PMID： 21105032      PMCID： PMC3037833          DOI： 10.1002/anie.201005575

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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Review 2.  PDZ domains-glue and guide.

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3.  WebLogo: a sequence logo generator.

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Review 4.  Small-molecule inhibitors of protein-protein interactions: progressing towards the dream.

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5.  Quantification of PDZ domain specificity, prediction of ligand affinity and rational design of super-binding peptides.

Authors:  Urs Wiedemann; Prisca Boisguerin; Rainer Leben; Dietmar Leitner; Gerd Krause; Karin Moelling; Rudolf Volkmer-Engert; Hartmut Oschkinat
Journal:  J Mol Biol       Date:  2004-10-22       Impact factor: 5.469

6.  Recognition of unique carboxyl-terminal motifs by distinct PDZ domains.

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8.  Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ.

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9.  A stabilizing influence: CAL PDZ inhibition extends the half-life of ΔF508-CFTR.

Authors:  Patrick R Cushing; Lars Vouilleme; Maria Pellegrini; Prisca Boisguerin; Dean R Madden
Journal:  Angew Chem Int Ed Engl       Date:  2010-12-17       Impact factor: 15.336

10.  EBP50, a beta-catenin-associating protein, enhances Wnt signaling and is over-expressed in hepatocellular carcinoma.

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1.  A Multireporter Bacterial 2-Hybrid Assay for the High-Throughput and Dynamic Assay of PDZ Domain-Peptide Interactions.

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2.  A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45.

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Review 3.  Emerging Themes in PDZ Domain Signaling: Structure, Function, and Inhibition.

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4.  Computational Analysis of Energy Landscapes Reveals Dynamic Features That Contribute to Binding of Inhibitors to CFTR-Associated Ligand.

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5.  Hybrid organic-inorganic inhibitors of a PDZ interaction that regulates the endocytic fate of CFTR.

Authors:  Rituparna Kundu; Patrick R Cushing; Brian V Popp; Yu Zhao; Dean R Madden; Zachary T Ball
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6.  Computational design of selective peptides to discriminate between similar PDZ domains in an oncogenic pathway.

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7.  MotifAnalyzer-PDZ: A computational program to investigate the evolution of PDZ-binding target specificity.

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8.  Stereochemical preferences modulate affinity and selectivity among five PDZ domains that bind CFTR: comparative structural and sequence analyses.

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9.  Stereochemical determinants of C-terminal specificity in PDZ peptide-binding domains: a novel contribution of the carboxylate-binding loop.

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Authors:  Melody Gao; Iain G P Mackley; Samaneh Mesbahi-Vasey; Haley A Bamonte; Sarah A Struyvenberg; Louisa Landolt; Nick J Pederson; Lucy I Williams; Christopher D Bahl; Lionel Brooks; Jeanine F Amacher
Journal:  Protein Sci       Date:  2020-09-25       Impact factor: 6.725
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