AIM: The purpose of this study is to detail the course of substance use disorders (SUDs) over 10 years of prospective follow-up among patients with borderline personality disorder (BPD) and Axis II comparison subjects. DESIGN: This study uses data from the McLean Study of Adult Development (MSAD), a multi-faceted study of the longitudinal course of BPD using reliable repeated measures administered every 2 years over a decade of prospective follow-up. SETTING: All subjects were initially in-patients at McLean Hospital in Belmont Massachusetts. PARTICIPANTS; A total of 290 patients with BPD and 72 Axis II comparison subjects were assessed at baseline and five waves of follow-up. MEASUREMENTS: The Structured Clinical Interview for DSM-III-R Axis I Disorders (SCID-I), the Revised Diagnostic Interview for Borderlines (DIB-R) and the Diagnostic Interview for DSM-III-R Personality Disorders (DIPD-R) were administered six times. Generalized estimating equations were used to assess longitudinal prevalence of SUDs. Kaplan-Meier analyses were used to assess time-to-remission, recurrence and new onsets of SUDs. RESULTS: The prevalence of SUDs among borderline patients and Axis II comparison subjects declined significantly over time, while remaining significantly more common among those with BPD. More than 90% of borderline patients meeting criteria for a SUD at baseline experienced a remission by 10-year follow-up. Recurrences and new onsets of SUDs were less common (35-40% and 21-23%). CONCLUSIONS: Remissions of alcohol and drug abuse/dependence among borderline patients are both common and relatively stable. Results also suggest that new onsets of these disorders are less common than might be expected.
AIM: The purpose of this study is to detail the course of substance use disorders (SUDs) over 10 years of prospective follow-up among patients with borderline personality disorder (BPD) and Axis II comparison subjects. DESIGN: This study uses data from the McLean Study of Adult Development (MSAD), a multi-faceted study of the longitudinal course of BPD using reliable repeated measures administered every 2 years over a decade of prospective follow-up. SETTING: All subjects were initially in-patients at McLean Hospital in Belmont Massachusetts. PARTICIPANTS; A total of 290 patients with BPD and 72 Axis II comparison subjects were assessed at baseline and five waves of follow-up. MEASUREMENTS: The Structured Clinical Interview for DSM-III-R Axis I Disorders (SCID-I), the Revised Diagnostic Interview for Borderlines (DIB-R) and the Diagnostic Interview for DSM-III-R Personality Disorders (DIPD-R) were administered six times. Generalized estimating equations were used to assess longitudinal prevalence of SUDs. Kaplan-Meier analyses were used to assess time-to-remission, recurrence and new onsets of SUDs. RESULTS: The prevalence of SUDs among borderline patients and Axis II comparison subjects declined significantly over time, while remaining significantly more common among those with BPD. More than 90% of borderline patients meeting criteria for a SUD at baseline experienced a remission by 10-year follow-up. Recurrences and new onsets of SUDs were less common (35-40% and 21-23%). CONCLUSIONS: Remissions of alcohol and drug abuse/dependence among borderline patients are both common and relatively stable. Results also suggest that new onsets of these disorders are less common than might be expected.
Authors: T H McGlashan; C M Grilo; A E Skodol; J G Gunderson; M T Shea; L C Morey; M C Zanarini; R L Stout Journal: Acta Psychiatr Scand Date: 2000-10 Impact factor: 6.392
Authors: Marsha M Linehan; Linda A Dimeff; Sarah K Reynolds; Katherine Anne Comtois; Stacy Shaw Welch; Patrick Heagerty; Daniel R Kivlahan Journal: Drug Alcohol Depend Date: 2002-06-01 Impact factor: 4.492
Authors: Deborah Hasin; Miriam C Fenton; Andrew Skodol; Robert Krueger; Katherine Keyes; Timothy Geier; Eliana Greenstein; Carlos Blanco; Bridget Grant Journal: Arch Gen Psychiatry Date: 2011-11
Authors: Kathryn R Cullen; Lori L LaRiviere; Nathalie Vizueta; Kathleen M Thomas; Ruskin H Hunt; Michael J Miller; Kelvin O Lim; Sellman C Schulz Journal: Brain Imaging Behav Date: 2016-06 Impact factor: 3.978
Authors: R Rossi; M Lanfredi; M Pievani; M Boccardi; P E Rasser; P M Thompson; E Cavedo; M Cotelli; S Rosini; R Beneduce; S Bignotti; L R Magni; L Rillosi; S Magnaldi; M Cobelli; G Rossi; G B Frisoni Journal: Eur Psychiatry Date: 2015-01-02 Impact factor: 5.361
Authors: Kathryn R Cullen; Nathalie Vizueta; Kathleen M Thomas; Georges J Han; Kelvin O Lim; Jazmin Camchong; Bryon A Mueller; Christopher H Bell; Monika D Heller; S Charles Schulz Journal: Brain Connect Date: 2011
Authors: Vassilis N Panagopoulos; Timothy J Trull; Anne L Glowinski; Michael T Lynskey; Andrew C Heath; Arpana Agrawal; Anjali K Henders; Leanne Wallace; Alexandre A Todorov; Pamela A F Madden; Elizabeth Moore; Louisa Degenhardt; Nicholas G Martin; Grant W Montgomery; Elliot C Nelson Journal: Drug Alcohol Depend Date: 2012-12-12 Impact factor: 4.492