R Rossi1, M Lanfredi2, M Pievani3, M Boccardi3, P E Rasser4, P M Thompson5, E Cavedo6, M Cotelli7, S Rosini7, R Beneduce2, S Bignotti2, L R Magni2, L Rillosi2, S Magnaldi8, M Cobelli8, G Rossi2, G B Frisoni9. 1. Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy. Electronic address: rrossi@fatebenefratelli.it. 2. Unit of Psychiatry, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy. 3. LENITEM, Laboratory of Epidemiology, Neuroimaging, & Telemedicine, Istituto Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy. 4. Centre for translational Neuroscience and Mental Health, The University of Newcastle, New South Wales, Australia; Schizophrenia Research Institute, Darlinghurst, Australia; Hunter Medical Research Institute, Newcastle, Australia. 5. Imaging Genetics Center, Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA. 6. LENITEM, Laboratory of Epidemiology, Neuroimaging, & Telemedicine, Istituto Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy; Cognition, neuroimaging and brain diseases Laboratory, Centre de Recherche de l'Insitut du Cerveau et de la Moelle (CRICM) UMRS_975, Université Pierre-et-Marie-Curie, Paris, France. 7. Unit of Neuropsychology, IRCCS Istituto Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy. 8. Unit of Neuroradiology, Poliambulanza Hospital, Brescia, Italy. 9. LENITEM, Laboratory of Epidemiology, Neuroimaging, & Telemedicine, Istituto Centro San Giovanni di Dio-Fatebenefratelli, Brescia, Italy; Memory Clinic and LANVIE, Laboratory of Neuroimaging of Aging, University Hospitals, University of Geneva, Geneva, Switzerland.
Abstract
BACKGROUND: Borderline personality disorder (BPD) is a chronic condition with a strong impact on patients' affective, cognitive and social functioning. Neuroimaging techniques offer invaluable tools to understand the biological substrate of the disease. We aimed to investigate gray matter alterations over the whole cortex in a group of Borderline Personality Disorder (BPD) patients compared to healthy controls (HC). METHODS: Magnetic resonance-based cortical pattern matching was used to assess cortical gray matter density (GMD) in 26 BPD patients and in their age- and sex-matched HC (age: 38 ± 11; females: 16, 61%). RESULTS: BPD patients showed widespread lower cortical GMD compared to HC (4% difference) with peaks of lower density located in the dorsal frontal cortex, in the orbitofrontal cortex, the anterior and posterior cingulate, the right parietal lobe, the temporal lobe (medial temporal cortex and fusiform gyrus) and in the visual cortex (P<0.005). Our BPD subjects displayed a symmetric distribution of anomalies in the dorsal aspect of the cortical mantle, but a wider involvement of the left hemisphere in the mesial aspect in terms of lower density. A few restricted regions of higher density were detected in the right hemisphere. All regions remained significant after correction for multiple comparisons via permutation testing. CONCLUSIONS: BPD patients feature specific morphology of the cerebral structures involved in cognitive and emotional processing and social cognition/mentalization, consistent with clinical and functional data.
BACKGROUND:Borderline personality disorder (BPD) is a chronic condition with a strong impact on patients' affective, cognitive and social functioning. Neuroimaging techniques offer invaluable tools to understand the biological substrate of the disease. We aimed to investigate gray matter alterations over the whole cortex in a group of Borderline Personality Disorder (BPD) patients compared to healthy controls (HC). METHODS: Magnetic resonance-based cortical pattern matching was used to assess cortical gray matter density (GMD) in 26 BPD patients and in their age- and sex-matched HC (age: 38 ± 11; females: 16, 61%). RESULTS: BPD patients showed widespread lower cortical GMD compared to HC (4% difference) with peaks of lower density located in the dorsal frontal cortex, in the orbitofrontal cortex, the anterior and posterior cingulate, the right parietal lobe, the temporal lobe (medial temporal cortex and fusiform gyrus) and in the visual cortex (P<0.005). Our BPD subjects displayed a symmetric distribution of anomalies in the dorsal aspect of the cortical mantle, but a wider involvement of the left hemisphere in the mesial aspect in terms of lower density. A few restricted regions of higher density were detected in the right hemisphere. All regions remained significant after correction for multiple comparisons via permutation testing. CONCLUSIONS: BPD patients feature specific morphology of the cerebral structures involved in cognitive and emotional processing and social cognition/mentalization, consistent with clinical and functional data.
Authors: R Roncone; J Ventura; M Impallomeni; I R Falloon; P L Morosini; E Chiaravalle; M Casacchia Journal: Acta Psychiatr Scand Date: 1999-09 Impact factor: 6.392
Authors: Marina Boccardi; Giovanni B Frisoni; Robert D Hare; Enrica Cavedo; Pablo Najt; Michela Pievani; Paul E Rasser; Mikko P Laakso; Hannu J Aronen; Eila Repo-Tiihonen; Olli Vaurio; Paul M Thompson; Jari Tiihonen Journal: Psychiatry Res Date: 2011-06-15 Impact factor: 3.222
Authors: Roberta Rossi; Michela Pievani; Marco Lorenzi; Marina Boccardi; Rossella Beneduce; Stefano Bignotti; Genoveffa Borsci; Maria Cotelli; Panteleimon Giannakopoulos; Laura R Magni; Luciana Rillosi; Sandra Rosini; Giuseppe Rossi; Giovanni B Frisoni Journal: Psychiatry Res Date: 2012-11-10 Impact factor: 3.222
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