Literature DB >> 20409744

Current strategies for diversity-oriented synthesis.

Sivaraman Dandapani1, Lisa A Marcaurelle.   

Abstract

Compounds accessed through diversity-oriented synthesis (DOS) are showing promise in modulating the activities of several targets that are currently considered 'undruggable'. Recently many new DOS pathways have been developed employing multi-component reactions, cycloadditions, ring-closing metathesis and tandem processes. Functional group pairing and 'build/couple/pair' strategies have been described as a means for generating structural diversity. Efforts have also been directed towards developing DOS libraries based on privileged scaffolds. Recent studies have provided several compelling examples for the utility of DOS compounds for producing novel biological probes and application of DOS in the context of drug discovery is extremely appealing. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20409744     DOI： 10.1016/j.cbpa.2010.03.018

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  31 in total

1.  Grand challenge commentary: Accessing new chemical space for 'undruggable' targets.

Authors:  Sivaraman Dandapani; Lisa A Marcaurelle
Journal:  Nat Chem Biol       Date:  2010-12       Impact factor: 15.040

2.  Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules.

Authors:  Warren R J D Galloway; Albert Isidro-Llobet; David R Spring
Journal:  Nat Commun       Date:  2010-09-21       Impact factor: 14.919

Review 3.  Fine-tuning multiprotein complexes using small molecules.

Authors:  Andrea D Thompson; Amanda Dugan; Jason E Gestwicki; Anna K Mapp
Journal:  ACS Chem Biol       Date:  2012-07-23       Impact factor: 5.100

Review 4.  From laptop to benchtop to bedside: structure-based drug design on protein targets.

Authors:  Lu Chen; John K Morrow; Hoang T Tran; Sharangdhar S Phatak; Lei Du-Cuny; Shuxing Zhang
Journal:  Curr Pharm Des       Date:  2012       Impact factor: 3.116

Review 5.  Natural products as sources of new drugs over the 30 years from 1981 to 2010.

Authors:  David J Newman; Gordon M Cragg
Journal:  J Nat Prod       Date:  2012-02-08       Impact factor: 4.050

Review 6.  Chemical probes and drug leads from advances in synthetic planning and methodology.

Authors:  Christopher J Gerry; Stuart L Schreiber
Journal:  Nat Rev Drug Discov       Date:  2018-04-13       Impact factor: 84.694

7.  Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections.

Authors:  Paul A Clemons; J Anthony Wilson; Vlado Dančík; Sandrine Muller; Hyman A Carrinski; Bridget K Wagner; Angela N Koehler; Stuart L Schreiber
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-11       Impact factor: 11.205

8.  Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators.

Authors:  Donna M Huryn; Jeffrey L Brodsky; Kay M Brummond; Peter G Chambers; Benjamin Eyer; Alex W Ireland; Masaoki Kawasumi; Matthew G Laporte; Kayla Lloyd; Baptiste Manteau; Paul Nghiem; Bettina Quade; Sandlin P Seguin; Peter Wipf
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-18       Impact factor: 11.205

9.  Diversity-oriented synthesis of macrocyclic peptidomimetics.

Authors:  Albert Isidro-Llobet; Tiffanie Murillo; Paula Bello; Agostino Cilibrizzi; James T Hodgkinson; Warren R J D Galloway; Andreas Bender; Martin Welch; David R Spring
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-07       Impact factor: 11.205

10.  Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity.

Authors:  Paul A Wender; Jeremy L Baryza; Stacey E Brenner; Brian A DeChristopher; Brian A Loy; Adam J Schrier; Vishal A Verma
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-17       Impact factor: 11.205
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