PURPOSE: We previously proposed an oxidative balance score (OBS) and illustrated its practical application by using data from previously completed case-control studies of two neoplasms - sporadic colorectal adenoma and prostate cancer. In the present study we extend our analysis by substituting questionnaire-based measures with systemic biomarkers of pro- and anti-oxidant exposures. METHODS: Low, medium and high pro-oxidant exposures, and high, medium and low antioxidant exposures were assigned 0, 1 and 2 points, respectively and individual points for all exposures were then summed to calculate the overall score. Case and controls were compared using logistic regression analysis after adjusting for covariates. RESULTS: When OBS was treated as a continuous variable the adjusted odds ratios and 95% confidence intervals (CI) for each additional score point were the same: 0.90 (95% CI: 0.83-0.97) for each study. When the OBS was divided into three approximately equal intervals, a comparison of the lowest to highest category showed similar adjusted ORs (95% CIs) of 0.34 (0.13-0.88) and 0.34 (0.14-0.86) for colorectal adenoma and prostate cancer, respectively. CONCLUSIONS: Our analyses provide support for the stated hypothesis that combined measures of pro- and anti-oxidant exposures may be associated with oxidative stress-related conditions.
PURPOSE: We previously proposed an oxidative balance score (OBS) and illustrated its practical application by using data from previously completed case-control studies of two neoplasms - sporadic colorectal adenoma and prostate cancer. In the present study we extend our analysis by substituting questionnaire-based measures with systemic biomarkers of pro- and anti-oxidant exposures. METHODS: Low, medium and high pro-oxidant exposures, and high, medium and low antioxidant exposures were assigned 0, 1 and 2 points, respectively and individual points for all exposures were then summed to calculate the overall score. Case and controls were compared using logistic regression analysis after adjusting for covariates. RESULTS: When OBS was treated as a continuous variable the adjusted odds ratios and 95% confidence intervals (CI) for each additional score point were the same: 0.90 (95% CI: 0.83-0.97) for each study. When the OBS was divided into three approximately equal intervals, a comparison of the lowest to highest category showed similar adjusted ORs (95% CIs) of 0.34 (0.13-0.88) and 0.34 (0.14-0.86) for colorectal adenoma and prostate cancer, respectively. CONCLUSIONS: Our analyses provide support for the stated hypothesis that combined measures of pro- and anti-oxidant exposures may be associated with oxidative stress-related conditions.
Authors: Carla H van Gils; Roberd M Bostick; Mariana C Stern; Jack A Taylor Journal: Cancer Epidemiol Biomarkers Prev Date: 2002-11 Impact factor: 4.254
Authors: Sonia M Boyapati; Roberd M Bostick; Katherine A McGlynn; Michael F Fina; Walter M Roufail; Kim R Geisinger; James R Hebert; Ann Coker; Michael Wargovich Journal: Cancer Causes Control Date: 2004-06 Impact factor: 2.506
Authors: Keith G Hauret; Roberd M Bostick; Charles E Matthews; James R Hussey; Michael F Fina; Kim R Geisinger; Walter M Roufail Journal: Am J Epidemiol Date: 2004-05-15 Impact factor: 4.897
Authors: Martha L Slattery; Abbie Lundgreen; Bill Welbourn; Roger K Wolff; Christopher Corcoran Journal: Mutat Res Date: 2012-04-15 Impact factor: 2.433
Authors: So Yeon J Kong; Roberd M Bostick; W Dana Flanders; William M McClellan; Bharat Thyagarajan; Myron D Gross; Suzanne Judd; Michael Goodman Journal: Cancer Epidemiol Biomarkers Prev Date: 2014-01-17 Impact factor: 4.254
Authors: So Yeon Kong; Michael Goodman; Suzanne Judd; Roberd M Bostick; W Dana Flanders; William McClellan Journal: Ann Epidemiol Date: 2015-01-16 Impact factor: 3.797
Authors: Julia Labadie; Michael Goodman; Bharat Thyagarajan; Myron Gross; Yan Sun; Veronika Fedirko; Roberd M Bostick Journal: Ann Epidemiol Date: 2013-01-03 Impact factor: 3.797
Authors: Titilayo O Ilori; Young Sun Ro; So Yeon Kong; Orlando M Gutierrez; Akinlolu O Ojo; Suzanne E Judd; K M Venkat Narayan; Michael Goodman; Laura Plantinga; William McClellan Journal: Am J Nephrol Date: 2015-11-17 Impact factor: 3.754
Authors: Sindhu Lakkur; Michael Goodman; Roberd M Bostick; Jessica Citronberg; William McClellan; William Dana Flanders; Suzanne Judd; Victoria L Stevens Journal: Ann Epidemiol Date: 2014-03-21 Impact factor: 3.797