Literature DB >> 21070847

A live attenuated Listeria monocytogenes vaccine vector expressing SIV Gag is safe and immunogenic in macaques and can be administered repeatedly.

Gaia Sciaranghella1, Samir K Lakhashe, Mila Ayash-Rashkovsky, Saied Mirshahidi, Nagadenahalli B Siddappa, Francis J Novembre, Vijayakumar Velu, Rama Rao Amara, Chenghui Zhou, Sufen Li, Zhongxia Li, Fred R Frankel, Ruth M Ruprecht.   

Abstract

Listeria monocytogenes (Lm) is known to induce strong cellular immune responses. We constructed a live-attenuated Lm vector, Lmdd-BdopSIVgag, which encodes SIVmac239 gag. Intragastric (i.g.) administration of 3 × 10(12) bacteria to rhesus macaques was safe and induced anti-Gag cellular but no humoral immune responses. Boosting of Gag-specific cellular responses was observed after i.g. administration of Lmdd-BdopSIVgag to previously vaccinated RM despite preexisting anti-Lm immunity shown by lymphoproliferative responses. Surprisingly, anti-Lm cellular responses were also detected in non-vaccinated controls, which may reflect the fact that Lm is a ubiquitous bacterium. The novel, live-attenuated Lmdd-BdopSIVgag may be an attractive platform for oral vaccine delivery. Copyright Â
© 2010 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 21070847      PMCID： PMC3039419          DOI： 10.1016/j.vaccine.2010.10.072

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  58 in total

1.  Recombinant Listeria monocytogenes vaccination eliminates papillomavirus-induced tumors and prevents papilloma formation from viral DNA.

Authors:  E R Jensen; R Selvakumar; H Shen; R Ahmed; F O Wettstein; J F Miller
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

2.  The host response to Listeria monocytogenes mutants defective in genes encoding phospholipases C (plcA, plcB) and actin assembly (actA).

Authors:  W Rudnicka; M Kaczmarek; J Szeliga; T Germann; M Wieckowska; B Rózalska
Journal:  Microbiol Immunol       Date:  1997       Impact factor: 1.955

3.  Induction of cell-mediated immune responses to human immunodeficiency virus type 1 Gag protein by using Listeria monocytogenes as a live vaccine vector.

Authors:  F R Frankel; S Hegde; J Lieberman; Y Paterson
Journal:  J Immunol       Date:  1995-11-15       Impact factor: 5.422

4.  Hemolysin-producing Listeria monocytogenes affects the immune response to T-cell-dependent and T-cell-independent antigens.

Authors:  C M Hage-Chahine; G Del Giudice; P H Lambert; J C Pechere
Journal:  Infect Immun       Date:  1992-04       Impact factor: 3.441

5.  Feeding trials of Listeria monocytogenes with a nonhuman primate model.

Authors:  J M Farber; E Daley; F Coates; N Beausoleil; J Fournier
Journal:  J Clin Microbiol       Date:  1991-11       Impact factor: 5.948

6.  New use of BCG for recombinant vaccines.

Authors:  C K Stover; V F de la Cruz; T R Fuerst; J E Burlein; L A Benson; L T Bennett; G P Bansal; J F Young; M H Lee; G F Hatfull
Journal:  Nature       Date:  1991-06-06       Impact factor: 49.962

7.  The ability of two Listeria monocytogenes vaccines targeting human papillomavirus-16 E7 to induce an antitumor response correlates with myeloid dendritic cell function.

Authors:  Xiaohui Peng; S Farzana Hussain; Yvonne Paterson
Journal:  J Immunol       Date:  2004-05-15       Impact factor: 5.422

8.  Listeria-based cancer vaccines that segregate immunogenicity from toxicity.

Authors:  Dirk G Brockstedt; Martin A Giedlin; Meredith L Leong; Keith S Bahjat; Yi Gao; William Luckett; Weiqun Liu; David N Cook; Daniel A Portnoy; Thomas W Dubensky
Journal:  Proc Natl Acad Sci U S A       Date:  2004-09-13       Impact factor: 11.205

9.  Listeria monocytogenes as a vaccine vector: virulence attenuation or existing antivector immunity does not diminish therapeutic efficacy.

Authors:  Holly Starks; Kevin W Bruhn; Hao Shen; Ronald A Barry; Thomas W Dubensky; Dirk Brockstedt; David J Hinrichs; Darren E Higgins; Jeffrey F Miller; Martin Giedlin; H G Archie Bouwer
Journal:  J Immunol       Date:  2004-07-01       Impact factor: 5.422

10.  Pathogenicity and immunogenicity of a Listeria monocytogenes strain that requires D-alanine for growth.

Authors:  R J Thompson; H G Bouwer; D A Portnoy; F R Frankel
Journal:  Infect Immun       Date:  1998-08       Impact factor: 3.441
View more
  7 in total

1.  Advances in bacterial cancer therapies using synthetic biology.

Authors:  Tiffany Chien; Anjali Doshi; Tal Danino
Journal:  Curr Opin Syst Biol       Date:  2017-05-23

2.  Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges.

Authors:  Samir K Lakhashe; Vijayakumar Velu; Gaia Sciaranghella; Nagadenahalli B Siddappa; Janet M Dipasquale; Girish Hemashettar; John K Yoon; Robert A Rasmussen; Feng Yang; Sandra J Lee; David C Montefiori; Francis J Novembre; François Villinger; Rama Rao Amara; Maria Kahn; Shiu-Lok Hu; Sufen Li; Zhongxia Li; Fred R Frankel; Marjorie Robert-Guroff; Welkin E Johnson; Judy Lieberman; Ruth M Ruprecht
Journal:  Vaccine       Date:  2011-07-14       Impact factor: 3.641

Review 3.  Dendritic cell-based immunity and vaccination against hepatitis C virus infection.

Authors:  Yun Zhou; Ying Zhang; Zhiqiang Yao; Jonathan Patrick Moorman; Zhansheng Jia
Journal:  Immunology       Date:  2012-08       Impact factor: 7.397

4.  Episomal expression of truncated listeriolysin O in LmddA-LLO-E7 vaccine enhances antitumor efficacy by preferentially inducing expansions of CD4+FoxP3- and CD8+ T cells.

Authors:  Zhisong Chen; Laurent Ozbun; Namju Chong; Anu Wallecha; Jay A Berzofsky; Samir N Khleif
Journal:  Cancer Immunol Res       Date:  2014-05-28       Impact factor: 11.151

5.  SHIV antigen immunization alters patterns of immune responses to SHIV/malaria coinfection and protects against life-threatening SHIV-related malaria.

Authors:  James T Frencher; Bridgett K Ryan-Pasyeur; Dan Huang; Ri Cheng Wang; Phillip D McMullen; Norman L Letvin; William E Collins; Nancy E Freitag; Miroslav Malkovsky; Crystal Y Chen; Ling Shen; Zheng W Chen
Journal:  J Infect Dis       Date:  2013-04-08       Impact factor: 5.226

6.  The attenuated hepatocellular carcinoma-specific Listeria vaccine Lmdd-MPFG prevents tumor occurrence through immune regulation of dendritic cells.

Authors:  Xin Wan; Ci Cheng; Zhe Lin; Runqiu Jiang; Wei Zhao; Xin Yan; Junwei Tang; Kun Yao; Beicheng Sun; Yun Chen
Journal:  Oncotarget       Date:  2015-04-20

Review 7.  Bacteria and cells as alternative nano-carriers for biomedical applications.

Authors:  Rafaela García-Álvarez; María Vallet-Regí
Journal:  Expert Opin Drug Deliv       Date:  2022-01-25       Impact factor: 6.648
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.