Literature DB >> 1904554

New use of BCG for recombinant vaccines.

C K Stover1, V F de la Cruz, T R Fuerst, J E Burlein, L A Benson, L T Bennett, G P Bansal, J F Young, M H Lee, G F Hatfull.   

Abstract

BCG, a live attenuated tubercle bacillus, is the most widely used vaccine in the world and is also a useful vaccine vehicle for delivering protective antigens of multiple pathogens. Extrachromosomal and integrative expression vectors carrying the regulatory sequences for major BCG heat-shock proteins have been developed to allow expression of foreign antigens in BCG. These recombinant BCG strains can elicit long-lasting humoral and cellular immune responses to foreign antigens in mice.

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Year:  1991        PMID： 1904554     DOI： 10.1038/351456a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  613 in total

1.  Mycobacterial infection of macrophages results in membrane-permeable phagosomes.

Authors:  R Teitelbaum; M Cammer; M L Maitland; N E Freitag; J Condeelis; B R Bloom
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-21       Impact factor: 11.205

Review 2.  Mycobacteria: bugs and bugbears (two steps forward and one step back).

Authors:  T Parish; N G Stoker
Journal:  Mol Biotechnol       Date:  1999-12-15       Impact factor: 2.695

3.  Plasmidic versus insertional cloning of heterologous genes in Mycobacterium bovis BCG: impact on in vivo antigen persistence and immune responses.

Authors:  I Méderlé; I Bourguin; D Ensergueix; E Badell; J Moniz-Peireira; B Gicquel; N Winter
Journal:  Infect Immun       Date:  2002-01       Impact factor: 3.441

4.  Comparative protective effects of recombinant DNA and Mycobacterium bovis bacille Calmette-Guérin vaccines against M. avium infection.

Authors:  E Martin; J A Triccas; A T Kamath; N Winter; W J Britton
Journal:  Clin Exp Immunol       Date:  2001-12       Impact factor: 4.330

5.  Inactivation and augmentation of the primary 3-ketosteroid-{delta}1- dehydrogenase in Mycobacterium neoaurum NwIB-01: biotransformation of soybean phytosterols to 4-androstene- 3,17-dione or 1,4-androstadiene-3,17-dione.

Authors:  Wei Wei; Feng-Qing Wang; Shu-Yue Fan; Dong-Zhi Wei
Journal:  Appl Environ Microbiol       Date:  2010-05-07       Impact factor: 4.792

6.  Lipid droplet-associated proteins are involved in the biosynthesis and hydrolysis of triacylglycerol in Mycobacterium bovis bacillus Calmette-Guerin.

Authors:  Kai Leng Low; Guanghou Shui; Klaus Natter; Wee Kiang Yeo; Sepp D Kohlwein; Thomas Dick; Srinivasa P S Rao; Markus R Wenk
Journal:  J Biol Chem       Date:  2010-05-06       Impact factor: 5.157

7.  Rv1218c, an ABC transporter of Mycobacterium tuberculosis with implications in drug discovery.

Authors:  Meenakshi Balganesh; Sanjana Kuruppath; Nimi Marcel; Sreevalli Sharma; Anju Nair; Umender Sharma
Journal:  Antimicrob Agents Chemother       Date:  2010-10-04       Impact factor: 5.191

8.  Antigen 84, an effector of pleiomorphism in Mycobacterium smegmatis.

Authors:  Liem Nguyen; Nicole Scherr; John Gatfield; Anne Walburger; Jean Pieters; Charles J Thompson
Journal:  J Bacteriol       Date:  2007-08-31       Impact factor: 3.490

9.  A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae.

Authors:  Kevin A Nash; Barbara A Brown-Elliott; Richard J Wallace
Journal:  Antimicrob Agents Chemother       Date:  2009-01-26       Impact factor: 5.191

10.  Parallel in vivo experimental evolution reveals that increased stress resistance was key for the emergence of persistent tuberculosis bacilli.

Authors:  Aideen C Allen; Wladimir Malaga; Cyril Gaudin; Arnaud Volle; Flavie Moreau; Ali Hassan; Catherine Astarie-Dequeker; Antonio Peixoto; Rudy Antoine; Alexandre Pawlik; Wafa Frigui; Céline Berrone; Roland Brosch; Philip Supply; Christophe Guilhot
Journal:  Nat Microbiol       Date:  2021-07-22       Impact factor: 17.745
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