| Literature DB >> 23568175 |
James T Frencher1, Bridgett K Ryan-Pasyeur, Dan Huang, Ri Cheng Wang, Phillip D McMullen, Norman L Letvin, William E Collins, Nancy E Freitag, Miroslav Malkovsky, Crystal Y Chen, Ling Shen, Zheng W Chen.
Abstract
Whether vaccination against a virus can protect against more virulent coinfection with the virus and additional pathogen(s) remains poorly characterized. Overlapping endemicity of human immunodeficiency virus (HIV) and malaria suggests that HIV/malaria coinfection frequently complicates acute and chronic HIV infection. Here we showed that vaccination of macaques with recombinant Listeria ΔactA prfA* expressing simian/human immunodeficiency virus (SHIV) gag and env elicited Gag- and Env-specific T-cell responses, and protected against life-threatening SHIV-related malaria after SHIV/Plasmodium fragile coinfection. SHIV antigen immunization reduced peak viremia, resisted SHIV/malaria-induced lymphoid destruction, and blunted coinfection-accelerated decline of CD4(+) T-cell counts after SHIV/malaria coinfection. SHIV antigen immunization also weakened coinfection-driven overreactive proinflammatory interferon-γ (IFNγ) responses and led to developing T helper cell 17/22 (Th17/Th22) responses after SHIV/malaria coinfection. The findings suggest that vaccination against AIDS virus can alter patterns of immune responses to the SHIV/malaria coinfection and protect against life-threatening SHIV-related malaria.Entities:
Keywords: HIV/AIDS; T cell; co-infection; immunology; malaria; vaccination
Mesh：
Substances：
Year: 2013 PMID： 23568175 PMCID： PMC3685226 DOI： 10.1093/infdis/jit151
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226