Literature DB >> 21068308

Assessing neuronal metabolism in vivo by modeling imaging measures.

Olga Ciccarelli1, Ahmed T Toosy, Nicola De Stefano, Claudia A M Wheeler-Kingshott, David H Miller, Alan J Thompson.   

Abstract

Mitochondrial dysfunction contributes to the pathogenesis of many neurological diseases, including multiple sclerosis (MS), but is not directly measurable in vivo. We modeled N-acetyl-aspartate (NAA), which reflects axonal structural integrity and mitochondrial metabolism, with imaging measures of axonal structural integrity (axial diffusivity and cord cross-sectional area) to extract its mitochondrial metabolic contribution. Lower residual variance in NAA, reflecting reduced mitochondrial metabolism, was associated with greater clinical disability in MS, independent of structural damage.

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Year:  2010        PMID： 21068308      PMCID： PMC3044872          DOI： 10.1523/JNEUROSCI.3330-10.2010

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


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