Literature DB >> 21067210

Clerodane diterpenes from Casearia arguta that act as synergistic TRAIL sensitizers.

Emily L Whitson1, Cheryl L Thomas, Curtis J Henrich, Thomas J Sayers, James B McMahon, Tawnya C McKee.   

Abstract

Casearia arguta was investigated as part of the ongoing search for synergistic TRAIL (tumor necrosis factor-α-related apoptosis-inducing ligand) sensitizers. As a result of this study, argutins A-H, eight new highly oxygenated clerodane diterpenes, were isolated from the plant Casearia arguta collected in Guatemala. The modified Mosher ester method was utilized to establish the absolute configuration of argutins A and F. Each of the argutins showed varying levels of synergy with TRAIL. Argutin B showed the highest TRAIL sensitization; the synergistic effect of argutin B and TRAIL together was 3-fold greater than argutin B alone.

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Year:  2010        PMID： 21067210      PMCID： PMC3058848          DOI： 10.1021/np1004455

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  30 in total

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Journal:  J Nat Prod       Date:  2002-02       Impact factor: 4.050

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Journal:  Chem Pharm Bull (Tokyo)       Date:  1991-03       Impact factor: 1.645

Review 4.  The clinical trail of TRAIL.

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  10 in total

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6.  Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation.

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10.  The Antitumor Activity and Mechanism of a Natural Diterpenoid From Casearia graveolens.

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  10 in total

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