Literature DB >> 14709876

Two new cytotoxic clerodane diterpenoids from Casearia membranacea.

Ya-Ching Shen1, Li-Tung Wang, Chih-Hsin Wang, Ashraf Taha Khalil, Jih-Hwa Guh.   

Abstract

In addition to casearlucin A (3), two new clerodane diterpenes, caseamembrols A (1) and B (2) have been isolated from the leaves and twigs of Casearia membranacea by bioassay-guided fractionation. The structures of the new compounds were established on the basis of extensive 1D- and 2D-NMR spectroscopic analysis. Compounds 1-3 exhibited significant cytotoxicity against human prostate (PC-3) cancer cells.

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Year:  2004        PMID: 14709876     DOI: 10.1248/cpb.52.108

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN: 0009-2363            Impact factor:   1.645


  4 in total

Review 1.  Clerodane diterpenes: sources, structures, and biological activities.

Authors:  Rongtao Li; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Nat Prod Rep       Date:  2016-07-18       Impact factor: 13.423

2.  Cytotoxic clerodane diterpenoids and their hydrolysis products from Casearia nigrescens from the rainforest of Madagascar.

Authors:  Russell B Williams; Andrew Norris; James S Miller; Chris Birkinshaw; Fidy Ratovoson; Rabodo Andriantsiferana; Vincent E Rasamison; David G I Kingston
Journal:  J Nat Prod       Date:  2007-02       Impact factor: 4.050

3.  Clerodane diterpenes from Casearia arguta that act as synergistic TRAIL sensitizers.

Authors:  Emily L Whitson; Cheryl L Thomas; Curtis J Henrich; Thomas J Sayers; James B McMahon; Tawnya C McKee
Journal:  J Nat Prod       Date:  2010-11-10       Impact factor: 4.050

4.  Ent-Clerodane Diterpenes from the Bark of Croton oligandrus Pierre ex Hutch. and Assessment of Their Cytotoxicity against Human Cancer Cell Lines.

Authors:  Stephanie Tamdem Guetchueng; Lutfun Nahar; Kenneth James Ritchie; Fyaz Mahmood Daud Ismail; Andrew Robert Evans; Satyajit Dey Sarker
Journal:  Molecules       Date:  2018-02-13       Impact factor: 4.411

  4 in total

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