PURPOSE: The aim was to assess the feasibility of dual-energy computed tomography (DE-CT) for detection of peri-interventional re-bleeding in patients with aneurysmal subarachnoid hemorrhage (re-SAH). METHODS: For in vitro-analyses DE-CT of partially clotted blood intermixed with fresh blood containing contrast agent was performed. In a clinical setting, 4 patients routinely underwent DE-CT after suspected peri-interventional re-SAH. DE-CT source data images, iodine maps and virtual non-contrast images (VNC) were analyzed and regions-of-interest (ROI) measurements of density values were performed. RESULTS: In vitro experiments demonstrated the feasibility of DE-CT to discriminate between blood with and without contrast agent. In all patients peri-interventional re-SAH was confirmed by detection of extravasated iodine within the subarachnoid spaces in post-interventional DE-CT. Dual-energy CT allowed the discrimination of old blood clots of the initial SAH and blood originating from peri-interventional re-SAH. After subtraction of the iodine-related high density signal, VNC images optimized the estimation of the true amount of subarachnoid blood. CONCLUSION: Dual-energy CT allows the discrimination and subtraction of blood and iodine mixed within the subarachnoid spaces in patients with peri-interventional re-SAH. It helps to avoid overestimation of SAH after peri-interventional re-bleeding and therefore is a potentially valuable tool in the assessment of peri-interventional re-SAH.
PURPOSE: The aim was to assess the feasibility of dual-energy computed tomography (DE-CT) for detection of peri-interventional re-bleeding in patients with aneurysmal subarachnoid hemorrhage (re-SAH). METHODS: For in vitro-analyses DE-CT of partially clotted blood intermixed with fresh blood containing contrast agent was performed. In a clinical setting, 4 patients routinely underwent DE-CT after suspected peri-interventional re-SAH. DE-CT source data images, iodine maps and virtual non-contrast images (VNC) were analyzed and regions-of-interest (ROI) measurements of density values were performed. RESULTS: In vitro experiments demonstrated the feasibility of DE-CT to discriminate between blood with and without contrast agent. In all patients peri-interventional re-SAH was confirmed by detection of extravasated iodine within the subarachnoid spaces in post-interventional DE-CT. Dual-energy CT allowed the discrimination of old blood clots of the initial SAH and blood originating from peri-interventional re-SAH. After subtraction of the iodine-related high density signal, VNC images optimized the estimation of the true amount of subarachnoid blood. CONCLUSION: Dual-energy CT allows the discrimination and subtraction of blood and iodine mixed within the subarachnoid spaces in patients with peri-interventional re-SAH. It helps to avoid overestimation of SAH after peri-interventional re-bleeding and therefore is a potentially valuable tool in the assessment of peri-interventional re-SAH.
Authors: Thorsten R C Johnson; Konstantin Nikolaou; Bernd J Wintersperger; Alexander W Leber; Franz von Ziegler; Carsten Rist; Sonja Buhmann; Andreas Knez; Maximilian F Reiser; Christoph R Becker Journal: Eur Radiol Date: 2006-05-13 Impact factor: 5.315
Authors: Thorsten R C Johnson; Bernhard Krauss; Martin Sedlmair; Michael Grasruck; Herbert Bruder; Dominik Morhard; Christian Fink; Sabine Weckbach; Miriam Lenhard; Bernhard Schmidt; Thomas Flohr; Maximilian F Reiser; Christoph R Becker Journal: Eur Radiol Date: 2006-12-07 Impact factor: 5.315
Authors: Joel G Fletcher; Naoki Takahashi; Robert Hartman; Luis Guimaraes; James E Huprich; David M Hough; Lifeng Yu; Cynthia H McCollough Journal: Radiol Clin North Am Date: 2009-01 Impact factor: 2.303
Authors: Wieland H Sommer; Thorsten R Johnson; Christoph R Becker; Elisabeth Arnoldi; Harald Kramer; Maximilian F Reiser; Konstantin Nikolaou Journal: Invest Radiol Date: 2009-05 Impact factor: 6.016
Authors: Jirí Ferda; Milan Novák; Hynek Mírka; Jan Baxa; Eva Ferdová; Alena Bednárová; Thomas Flohr; Bernhard Schmidt; Ernst Klotz; Boris Kreuzberg Journal: Eur Radiol Date: 2009-07-08 Impact factor: 5.315
Authors: Paul Stolzmann; Marko Kozomara; Natalie Chuck; Michael Müntener; Sebastian Leschka; Hans Scheffel; Hatem Alkadhi Journal: Abdom Imaging Date: 2009-09-02
Authors: Dominik Morhard; Christian Fink; Anno Graser; Maximilian F Reiser; Christoph Becker; Thorsten R C Johnson Journal: Invest Radiol Date: 2009-05 Impact factor: 6.016
Authors: A E Grams; M Knoflach; R Rehwald; J Willeit; M Sojer; E R Gizewski; B Glodny Journal: AJNR Am J Neuroradiol Date: 2015-05-21 Impact factor: 3.825
Authors: Tanja Djurdjevic; Rafael Rehwald; Michael Knoflach; Benjamin Matosevic; Stefan Kiechl; Elke Ruth Gizewski; Bernhard Glodny; Astrid Ellen Grams Journal: Eur Radiol Date: 2016-06-02 Impact factor: 5.315
Authors: Astrid Ellen Grams; Tanja Djurdjevic; Rafael Rehwald; Thomas Schiestl; Florian Dazinger; Ruth Steiger; Michael Knoflach; Elke Ruth Gizewski; Bernhard Glodny Journal: Eur Radiol Date: 2018-05-04 Impact factor: 5.315