Tomislav Friščić1, William Jones. 1. Pfizer Institute for Pharmaceutical Materials Science and Department of Chemistry, University of Cambridge, Lensfield Road,Cambridge CB21EW, UK. tf253@cam.ac.uk
Abstract
OBJECTIVES: We provide a brief overview of recent applications of cocrystals for improving the physico-chemical and materials properties of active pharmaceutical ingredients, including solubility, humidity and thermal stability, dissolution rates and compressibility for tablet formation. KEY FINDINGS: This overview illustrates the pharmaceutical applications of cocrystals, with a selection of recent examples and also attempts to foresee future developments by proposing several directions not yet explored in the area of pharmaceutical cocrystallisation. SUMMARY: Reliable strategies for the synthesis and design of pharmaceutical cocrystals have now been established, and the potential of cocrystallisation for enhancing the solid-state properties of drugs is well recognised; the field is now moving towards the understanding of cocrystal structure-property relationships, for which systematic structural studies and computational approaches will play a key role.
OBJECTIVES: We provide a brief overview of recent applications of cocrystals for improving the physico-chemical and materials properties of active pharmaceutical ingredients, including solubility, humidity and thermal stability, dissolution rates and compressibility for tablet formation. KEY FINDINGS: This overview illustrates the pharmaceutical applications of cocrystals, with a selection of recent examples and also attempts to foresee future developments by proposing several directions not yet explored in the area of pharmaceutical cocrystallisation. SUMMARY: Reliable strategies for the synthesis and design of pharmaceutical cocrystals have now been established, and the potential of cocrystallisation for enhancing the solid-state properties of drugs is well recognised; the field is now moving towards the understanding of cocrystal structure-property relationships, for which systematic structural studies and computational approaches will play a key role.
Authors: Manza B J Atkinson; S V Santhana Mariappan; Dejan-Krešimir Bučar; Jonas Baltrusaitis; Tomislav Friščić; Naif G Sinada; Leonard R MacGillivray Journal: Proc Natl Acad Sci U S A Date: 2011-06-20 Impact factor: 11.205
Authors: Mizraín Solares-Briones; Guadalupe Coyote-Dotor; José C Páez-Franco; Miriam R Zermeño-Ortega; Carmen Myriam de la O Contreras; Daniel Canseco-González; Alcives Avila-Sorrosa; David Morales-Morales; Juan M Germán-Acacio Journal: Pharmaceutics Date: 2021-05-25 Impact factor: 6.321
Authors: Irena Sović; Stipe Lukin; Ernest Meštrović; Ivan Halasz; Andrea Porcheddu; Francesco Delogu; Pier Carlo Ricci; Fabien Caron; Thomas Perilli; Anita Dogan; Evelina Colacino Journal: ACS Omega Date: 2020-10-30