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Literature DB >> 21037290

Production of glutaconic acid in a recombinant Escherichia coli strain.

Ivana Djurdjevic¹, Oskar Zelder, Wolfgang Buckel.

Abstract

The assembly of six genes that encode enzymes from glutamate-fermenting bacteria converted Escherichia coli into a glutaconate producer when grown anaerobically on a complex medium. The new anaerobic pathway starts with 2-oxoglutarate from general metabolism and proceeds via (R)-2-hydroxyglutarate, (R)-2-hydroxyglutaryl-coenzyme A (CoA), and (E)-glutaconyl-CoA to yield 2.7 ± 0.2 mM (E)-glutaconate in the medium.

Entities: Chemical Species

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Year: 2010 PMID： 21037290 PMCID： PMC3019735 DOI： 10.1128/AEM.02049-10

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

13 in total

1. 2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum.

Authors: M Hans; J Sievers; U Müller; E Bill; J A Vorholt; D Linder; W Buckel
Journal: Eur J Biochem Date: 1999-10-01

Review 2. Unusual enzymes involved in five pathways of glutamate fermentation.

Authors: W Buckel
Journal: Appl Microbiol Biotechnol Date: 2001-10 Impact factor: 4.813

3. The iron-sulfur clusters in 2-hydroxyglutaryl-CoA dehydratase from Acidaminococcus fermentans. Biochemical and spectroscopic investigations.

Authors: M Hans; W Buckel; E Bill
Journal: Eur J Biochem Date: 2000-12

4. Structural basis for stereo-specific catalysis in NAD(+)-dependent (R)-2-hydroxyglutarate dehydrogenase from Acidaminococcus fermentans.

Authors: Berta M Martins; Sandra Macedo-Ribeiro; Julia Bresser; Wolfgang Buckel; Albrecht Messerschmidt
Journal: FEBS J Date: 2005-01 Impact factor: 5.542

5. Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli.

Authors: Bryson D Bennett; Elizabeth H Kimball; Melissa Gao; Robin Osterhout; Stephen J Van Dien; Joshua D Rabinowitz
Journal: Nat Chem Biol Date: 2009-06-28 Impact factor: 15.040

6. On the mechanism of action of the antifungal agent propionate.

Authors: Matthias Brock; Wolfgang Buckel
Journal: Eur J Biochem Date: 2004-08

7. Glutaconate CoA-transferase from Acidaminococcus fermentans.

Authors: W Buckel; U Dorn; R Semmler
Journal: Eur J Biochem Date: 1981-08

8. Location of the two genes encoding glutaconate coenzyme A-transferase at the beginning of the hydroxyglutarate operon in Acidaminococcus fermentans.

Authors: M Mack; K Bendrat; O Zelder; E Eckel; D Linder; W Buckel
Journal: Eur J Biochem Date: 1994-11-15

9. A sodium ion gradient as energy source for Peptostreptococcus asaccharolyticus.

Authors: G Wohlfarth; W Buckel
Journal: Arch Microbiol Date: 1985-07 Impact factor: 2.552

10. Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway.

Authors: Tobias J Erb; Ivan A Berg; Volker Brecht; Michael Müller; Georg Fuchs; Birgit E Alber
Journal: Proc Natl Acad Sci U S A Date: 2007-06-04 Impact factor: 11.205

6 in total

1. Structural and Functional Characterization of an Electron Transfer Flavoprotein Involved in Toluene Degradation in Strictly Anaerobic Bacteria.

Authors: Marian Samuel Vogt; Karola Schühle; Sebastian Kölzer; Patrick Peschke; Nilanjan Pal Chowdhury; Daniel Kleinsorge; Wolfgang Buckel; Lars-Oliver Essen; Johann Heider
Journal: J Bacteriol Date: 2019-10-04 Impact factor: 3.490