Literature DB >> 20959903

Computational design of orthogonal nucleoside kinases.

Lingfeng Liu1, Paul Murphy, David Baker, Stefan Lutz.   

Abstract

We report the computational enzyme design of an orthogonal nucleoside analog kinase for 3'-deoxythymidine. The best kinase variant shows an 8500-fold change in substrate specificity, resulting from a 4.6-fold gain in catalytic efficiency for the nucleoside analog and a 2000-fold decline for the native substrate thymidine.

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Year:  2010        PMID： 20959903      PMCID： PMC3733048          DOI： 10.1039/c0cc02961k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  17 in total

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Authors:  B Kuhlman; D Baker
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2.  Computational redesign of protein-protein interaction specificity.

Authors:  Tanja Kortemme; Lukasz A Joachimiak; Alex N Bullock; Aaron D Schuler; Barry L Stoddard; David Baker
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Review 3.  Twenty-six years of anti-HIV drug discovery: where do we stand and where do we go?

Authors:  Youcef Mehellou; Erik De Clercq
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4.  De novo protein design: fully automated sequence selection.

Authors:  B I Dahiyat; S L Mayo
Journal:  Science       Date:  1997-10-03       Impact factor: 47.728

5.  Effects of 2',3'-dideoxynucleosides on mammalian cells and viruses.

Authors:  M A Waqar; M J Evans; K F Manly; R G Hughes; J A Huberman
Journal:  J Cell Physiol       Date:  1984-11       Impact factor: 6.384

6.  DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity.

Authors:  Shiwei Song; Zachary F Pursell; William C Copeland; Matthew J Longley; Thomas A Kunkel; Christopher K Mathews
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7.  Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.

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Journal:  Cancer Res       Date:  1986-10       Impact factor: 12.701

8.  Structural basis for feedback inhibition of the deoxyribonucleoside salvage pathway: studies of the Drosophila deoxyribonucleoside kinase.

Authors:  Nils Egil Mikkelsen; Kenth Johansson; Andreas Karlsson; Wolfgang Knecht; Gorm Andersen; Jure Piskur; Birgitte Munch-Petersen; Hans Eklund
Journal:  Biochemistry       Date:  2003-05-20       Impact factor: 3.162

9.  In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors.

Authors:  K W Culver; Z Ram; S Wallbridge; H Ishii; E H Oldfield; R M Blaese
Journal:  Science       Date:  1992-06-12       Impact factor: 47.728

Review 10.  Mammalian deoxyribonucleoside kinases.

Authors:  E S Arnér; S Eriksson
Journal:  Pharmacol Ther       Date:  1995       Impact factor: 12.310
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  5 in total

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Authors:  Fei Chen; Yuan Zhang; Ashley B Daugherty; Zunyi Yang; Ryan Shaw; Mengxing Dong; Stefan Lutz; Steven A Benner
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3.  A generic program for multistate protein design.

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Review 4.  Recent advances in rational approaches for enzyme engineering.

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Journal:  Comput Struct Biotechnol J       Date:  2012-10-22       Impact factor: 7.271

5.  Redesigning human 2'-deoxycytidine kinase enantioselectivity for L-nucleoside analogues as reporters in positron emission tomography.

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  5 in total

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