Literature DB >> 20953192

Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer.

Lisa M Miller Jenkins1, David E Ott, Ryo Hayashi, Lori V Coren, Deyun Wang, Qun Xu, Marco L Schito, John K Inman, Daniel H Appella, Ettore Appella.   

Abstract

The zinc fingers of the HIV-1 nucleocapsid protein, NCp7, are prime targets for antiretroviral therapeutics. Here we show that S-acyl-2-mercaptobenzamide thioester (SAMT) chemotypes inhibit HIV by modifying the NCp7 region of Gag in infected cells, thereby blocking Gag processing and reducing infectivity. The thiol produced by SAMT reaction with NCp7 is acetylated by cellular enzymes to regenerate active SAMTs via a recycling mechanism unique among small-molecule inhibitors of HIV.

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Year:  2010        PMID： 20953192      PMCID： PMC2997617          DOI： 10.1038/nchembio.456

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  21 in total

Review 1.  Topical microbicides: a promising approach for controlling the AIDS pandemic via retroviral zinc finger inhibitors.

Authors:  Jim A Turpin; Marco L Schito; Lisa M Miller Jenkins; John K Inman; Ettore Appella
Journal:  Adv Pharmacol       Date:  2008

Review 2.  Nucleocapsid protein function in early infection processes.

Authors:  James A Thomas; Robert J Gorelick
Journal:  Virus Res       Date:  2008-02-14       Impact factor: 3.303

Review 3.  Targeting the viral nucleocapsid protein in anti-HIV-1 therapy.

Authors:  Hugues de Rocquigny; Volodymyr Shvadchak; Sergiy Avilov; Chang Zhi Dong; Ursula Dietrich; Jean-Luc Darlix; Yves Mély
Journal:  Mini Rev Med Chem       Date:  2008-01       Impact factor: 3.862

4.  Geographic and temporal trends of transmitted HIV-1 drug resistance among antiretroviral-naïve subjects screening for two clinical trials in North America and Western Europe.

Authors:  Sibtain Rahim; Linda M Fredrick; Barbara A da Silva; Barry Bernstein; Martin S King
Journal:  HIV Clin Trials       Date:  2009 Mar-Apr

5.  Prevalence of transmitted drug resistance associated mutations and HIV-1 subtypes in new HIV-1 diagnoses, U.S.-2006.

Authors:  William H Wheeler; Rebecca A Ziebell; Helena Zabina; Danuta Pieniazek; Joseph Prejean; Ulana R Bodnar; Kristen C Mahle; Walid Heneine; Jeffrey A Johnson; H Irene Hall
Journal:  AIDS       Date:  2010-05-15       Impact factor: 4.177

6.  HIV-1 Gag processing intermediates trans-dominantly interfere with HIV-1 infectivity.

Authors:  Barbara Müller; Maria Anders; Hisashi Akiyama; Sonja Welsch; Bärbel Glass; Krisztina Nikovics; Francois Clavel; Hanna-Mari Tervo; Oliver T Keppler; Hans-Georg Kräusslich
Journal:  J Biol Chem       Date:  2009-08-07       Impact factor: 5.157

7.  Alteration of zinc-binding residues of simian immunodeficiency virus p8(NC) results in subtle differences in gag processing and virion maturation associated with degradative loss of mutant NC.

Authors:  J L Yovandich; E N Chertova; B P Kane; T D Gagliardi; J W Bess; R C Sowder; L E Henderson; R J Gorelick
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

8.  Primary antiretroviral drug resistance among HIV type 1-infected individuals in Brazil.

Authors:  Eduardo Sprinz; Eduardo M Netto; Maria Patelli; J S Lima; Maria Patelli J S Lima; Juvênao J D Furtado; Margareth da Eira; Roberto Zajdenverg; José V Madruga; David S Lewi; Alcyone A Machado; Rogério J Pedro; Marcelo A Soares
Journal:  AIDS Res Hum Retroviruses       Date:  2009-09       Impact factor: 2.205

9.  Human immunodeficiency virus type 1 nucleocapsid inhibitors impede trans infection in cellular and explant models and protect nonhuman primates from infection.

Authors:  Gregory S Wallace; Cecilia Cheng-Mayer; Marco L Schito; Patricia Fletcher; Lisa M Miller Jenkins; Ryo Hayashi; A Robert Neurath; Ettore Appella; Robin J Shattock
Journal:  J Virol       Date:  2009-07-08       Impact factor: 5.103

Review 10.  Understanding the Warburg effect: the metabolic requirements of cell proliferation.

Authors:  Matthew G Vander Heiden; Lewis C Cantley; Craig B Thompson
Journal:  Science       Date:  2009-05-22       Impact factor: 47.728
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  23 in total

1.  A one-pot preparation of N-2-mercaptobenzoyl-amino amides.

Authors:  Robert J Bahde; Daniel H Appella; William C Trenkle
Journal:  Tetrahedron Lett       Date:  2011-08-10       Impact factor: 2.415

2.  Delay of simian human immunodeficiency virus infection and control of viral replication in vaccinated macaques challenged in the presence of a topical microbicide.

Authors:  Cecilia Cheng-Mayer; Yaoxing Huang; Agegnehu Gettie; Lily Tsai; Wuze Ren; Madina Shakirzyanova; Silvana T Sina; Nataliya Trunova; James Blanchard; Lisa M Miller Jenkins; Yungtai Lo; Marco L Schito; Ettore Appella
Journal:  AIDS       Date:  2011-09-24       Impact factor: 4.177

Review 3.  HIV type 1 Gag as a target for antiviral therapy.

Authors:  Abdul A Waheed; Eric O Freed
Journal:  AIDS Res Hum Retroviruses       Date:  2011-09-21       Impact factor: 2.205

Review 4.  Advances in targeting nucleocapsid-nucleic acid interactions in HIV-1 therapy.

Authors:  Divita Garg; Bruce E Torbett
Journal:  Virus Res       Date:  2014-07-12       Impact factor: 3.303

5.  An Intravaginal Ring for the Simultaneous Delivery of an HIV-1 Maturation Inhibitor and Reverse-Transcriptase Inhibitor for Prophylaxis of HIV Transmission.

Authors:  Shweta R Ugaonkar; Justin T Clark; Lexie B English; Todd J Johnson; Karen W Buckheit; Robert J Bahde; Daniel H Appella; Robert W Buckheit; Patrick F Kiser
Journal:  J Pharm Sci       Date:  2015-07-06       Impact factor: 3.534

Review 6.  Beyond plasma membrane targeting: role of the MA domain of Gag in retroviral genome encapsidation.

Authors:  Leslie J Parent; Nicole Gudleski
Journal:  J Mol Biol       Date:  2011-07-22       Impact factor: 5.469

Review 7.  HIV-1 gag: an emerging target for antiretroviral therapy.

Authors:  Philip R Tedbury; Eric O Freed
Journal:  Curr Top Microbiol Immunol       Date:  2015       Impact factor: 4.291

8.  A perspective on progress and gaps in HIV prevention science.

Authors:  Patrick F Kiser; Pedro M M Mesquita; Betsy C Herold
Journal:  AIDS Res Hum Retroviruses       Date:  2012-11       Impact factor: 2.205

9.  Antagonizing the Androgen Receptor with a Biomimetic Acyltransferase.

Authors:  Yuchen Zhang; Pavan K Mantravadi; Soma Jobbagy; Wei Bao; John T Koh
Journal:  ACS Chem Biol       Date:  2016-08-26       Impact factor: 5.100

10.  An SAMT-247 Microbicide Provides Potent Protection against Intravaginal Simian Immunodeficiency Virus Infection of Rhesus Macaques, whereas an Added Vaccine Component Elicits Mixed Outcomes.

Authors:  Sabrina Helmold Hait; Christopher James Hogge; Mohammad Arif Rahman; Eun-Ju Ko; Ruth Hunegnaw; Zuena Mushtaq; Gospel Enyindah-Asonye; Tanya Hoang; Lisa M Miller Jenkins; Ettore Appella; Daniel H Appella; Marjorie Robert-Guroff
Journal:  J Immunol       Date:  2020-05-11       Impact factor: 5.422
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